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Table 3 Survival of patients with BM from SCLC: Historical comparison using prognostic classification systems

From: Upfront stereotactic radiosurgery in patients with brain metastases from small cell lung cancer: retrospective analysis of 41 patients

Author & year (No. of patients)

Present study (41)

Sperduto et al. 2010[22] (299)

Videtic et al. 2007[23] (154)

Rades et al. 2013[24] (86)

Initial treatment

    

SRS

100%

4%

1%

0%

WBRT

0%

83%

84%

100%

Patients with 1–3 BM

68%

61%

NA

28%

Overall MST in months

8.1

4.9

4.9

NA

DS-GPA (MST in months)

0-1.0

7.2 (20)

2.8

  

1.5-2.5

8.1 (15)

5.3

  

3.0

24.3 (5)

9.6

  

3.5-4.0

10.3 (1)

17.1

  

RTOG-RPA (MST in months)

Class III

6.7 (6)

 

2.5

 

Class II

8.3 (25)

 

5.3

 

Class I

9.2 (10)

 

8.6

 

Rades’ score (6-months survival rate)

5-8

44% (9)

  

3%

9-12

73% (22)

  

41%

15

80% (10)

  

89%

  1. BM brain metastases, SCLC small cell lung cancer, SRS stereotactic radiosurgery, WBRT whole brain radiotherapy, NA not available, MST median survival time, DS-GPA diagnosis specific-graded prognosis assessment, RTOG-RPA radiation treatment oncology group recursive partitioning analysis.