Parameter (No. of patients) | OS (months) | Univariate* | Multivariate** | |
---|---|---|---|---|
Median (95% CI) | P Value | P Value | HR (95% CI) | |
Age | 0.205 | 0.456 | 0.758 (0.363-1.58) | |
65 years or less (17) | 12.6 (6.2-20.5) | |||
More than 65 years (24) | 6.7 (4.4-13.3) | |||
KPS | < 0.001 | 0.009 | 0.308 (0.128-0.742) | |
90 or more (23) | 13.3 (6.7-24.2) | |||
Less than 90 (18) | 5.4 (4.3-12.2) | |||
Extra-CNS disease status | 0.005 | 0.450 | 0.674 (0.242 − 1.88) | |
None or inactive (16) | 18.0 (6.7-29.9) | |||
Active (25) | 6.7 (4.7-12.6) | |||
Post-SRS chemotherapy | 0.009 | 0.016 | 0.324 (0.130-0.809) | |
Yes (32) | 12.4 (6.7-18.0) | |||
No (9) | 5.2 (0.8-8.3) | |||
Total PTV at initial SRS | 0.063 | 0.672 | 0.842 (0.381-1.86) | |
5 mL or less (21) | 7.8 (6.2-24.2) | |||
More than 5 mL (20) | 8.2 (2.8-15.6) | |||
No. of BM | 0.011 | 0.161 | 0.551 (0.240-1.27) | |
Single (18) | 16.8 (5.2-29.9) | |||
Multiple (23) | 6.7 (4.7-12.2) |