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Table 2 Statistical analysis of factors predicting patient survival after SRS

From: Upfront stereotactic radiosurgery in patients with brain metastases from small cell lung cancer: retrospective analysis of 41 patients

Parameter (No. of patients)

OS (months)

Univariate*

Multivariate**

Median (95% CI)

P Value

P Value

HR (95% CI)

Age

 

0.205

0.456

0.758 (0.363-1.58)

65 years or less (17)

12.6 (6.2-20.5)

   

More than 65 years (24)

6.7 (4.4-13.3)

   

KPS

 

< 0.001

0.009

0.308 (0.128-0.742)

90 or more (23)

13.3 (6.7-24.2)

   

Less than 90 (18)

5.4 (4.3-12.2)

   

Extra-CNS disease status

 

0.005

0.450

0.674 (0.242 − 1.88)

None or inactive (16)

18.0 (6.7-29.9)

   

Active (25)

6.7 (4.7-12.6)

   

Post-SRS chemotherapy

 

0.009

0.016

0.324 (0.130-0.809)

Yes (32)

12.4 (6.7-18.0)

   

No (9)

5.2 (0.8-8.3)

   

Total PTV at initial SRS

 

0.063

0.672

0.842 (0.381-1.86)

5 mL or less (21)

7.8 (6.2-24.2)

   

More than 5 mL (20)

8.2 (2.8-15.6)

   

No. of BM

 

0.011

0.161

0.551 (0.240-1.27)

Single (18)

16.8 (5.2-29.9)

   

Multiple (23)

6.7 (4.7-12.2)

   
  1. SRS: stereotactic radiosurgery, OS: overall survival, CI: confidence interval, KPS: Karnofsky performance status, CNS: central nervous system, PTV: planning target volume, BM brain metastases.
  2. *Log-rank test.
  3. **Cox proportional hazards model.