Hafnium oxide nanoparticles: toward an in vitropredictive biological effect?

Radiation Oncology

Table 1 Toward a predictive NBTXR3 nanoparticle radioenhancement

		Onset of NBTXR3 nanoparticles concentration where equation 2 predicts an observable effect
Cell line	SF₂(mean ± SD)	[NBTXR3] μM (Onset)	DEF (2 Gy)
HCT 116	22.4 (±9.14)	800	2.2 (±0.55)
Hs913T	25.2 (±2.27)	400	2.8 (±0.36)
NCI H460-Luc2	36.0 (±3.2)	800	1.2 (±0.06)
42-MG-BA	37.3 (±2.53)	200	1.2 (±0.03)
HT-1080	38.9 (±1.39)	100	1.2 (±0.06)
PANC-1	40.6 (±6.64)	800	1.3 (±0.25)
CAL-33	64.8 (±2.12)	nd	nd
FaDu	66.0 (±6.78)	nd	nd

Onset of NBTXR3 nanoparticles concentrations where equation 2 predicts an observable effect are presented together with the corresponding measured mean DEF values at 2 Gy. nd: non determined.

ISSN: 1748-717X