The role of whole brain radiation therapy in the management of melanoma brain metastases

Radiation Oncology

Table 3 Model selection for overall survival

	Univariate analysis			Multivariate analysis
	HR	95% CI	p value	HR	95% CI	p value
Age at SRS (in years, continuous)*	1.00	0.98 – 1.01	0.46	0.99	0.98 – 1.01	0.37
Age at SRS >60 years	0.94	0.67 – 1.32	0.71
Time from primary to brain met <39 mo.	1.11	0.79 – 1.55	0.56
Extensive ECM (vs. Limited)^†	1.86	1.31 – 2.64	0.0006	1.78	1.25 – 2.53	0.001
Progressive ECD (vs. absent/stable)	1.22	0.82 – 1.82	0.32
Number of brain metastases >1	1.40	0.99 – 1.98	0.06
Diameter of brain metastasis >1 cm	1.24	0.89 – 1.75	0.21
KPS 50 – 80 (vs. 90 or 100)	1.58	1.12 – 2.21	0.01	1.52	1.08 – 2.15	0.02
Omission of up-front WBRT	0.96	0.66 – 1.41	0.85

Abbreviations: HR hazard ratio, CI confidence interval, SRS stereotactic radiosurgery, Met metastasis, ECM extracranial metastases, ECD extracranial disease, KPS Karnofsky Performance Status, WBRT whole brain radiation therapy.
*Age (as a continuous variable) was included in multivariate models for overall survival regardless of significance on univariate analysis.
^†See Materials and Methods section and Table 1 for definitions of extensive and limited extracranial metastases.

ISSN: 1748-717X