The role of whole brain radiation therapy in the management of melanoma brain metastases

Radiation Oncology

Table 2 Model selection for time to distant intracranial progression

	Univariate analysis			Multivariate analysis
	HR	95% CI	p value	HR	95% CI	p value
Age at SRS >60 years	0.66	0.43 – 1.01	0.05	0.64	0.41 – 0.99	0.05
Time from primary to brain met <39 mo.	1.16	0.76 – 1.77	0.50
Extensive ECM (vs. Limited)*	1.20	0.77 – 1.89	0.43
Progressive ECD (vs. absent/stable)	1.15	0.70 – 1.87	0.58
Number of brain metastases >1	1.45	0.93 – 2.24	0.10	1.90	1.18 – 3.06	0.008
Diameter of brain metastasis >1 cm	0.85	0.55 – 1.30	0.44
KPS 50 – 80 (vs. 90 or 100)	0.90	0.58 – 1.41	0.65
Omission of up-front WBRT	1.54	0.91 – 2.60	0.09	2.24	1.27 – 3.94	0.005

Abbreviations: HR hazard ratio, CI confidence interval, SRS stereotactic radiosurgery, Met metastasis, ECM extracranial metastases, ECD extracranial disease, KPS Karnofsky Performance Status, WBRT whole brain radiation therapy.
*See Materials and Methods section and Table 1 for definitions of “extensive” and “limited” extracranial metastases.

ISSN: 1748-717X