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Table 5 Multivariate analysis of lung and heart dosimetry and possible confounders in patients with chest wall and chest wall plus lymph nodes radiotherapy (n = 818)

From: No difference in dose distribution in organs at risk in postmastectomy radiotherapy with or without breast implant reconstruction

  

Chest wall

Chest wall plus lymph nodes

  

n = 242

n = 576

Outcome variable

Covariate

OR (95%CI)

P-value

OR (95%CI)

P-value

Lung V20Gy

     
 

IBR- vs. IBR+

1.7 (0.5 to 5.8)

0.41

0.6 (0.4 to 1.0)

0.07

 

Right vs. Left

1.1 (0.3 to 3.4)

0.91

1.1 (0.8 to 1.5)

0.59

 

CWi ≤ median vs. CWi > median

0.7 (0.2 to 2.2)

0.50

1.7 (1.2 to 2.3)

0.004

Heart Dmean*

 

n = 118*

n = 309*

 

IBR- vs. IBR+

-#

-

1.2 (0.5 to 3.1)

0.72

 

Right vs. Left

-

-

-

-

 

CWi ≤ median vs. CWi > median

0.2 (0.3 to 1.8)

0.16

0.9 (0.5 to 1.8)

0.82

  1. IBR, immediate breast reconstruction; CWi, chest wall index; OR, odds ratio; CI, confidence interval.
  2. Lung V20Gy, volume of ipsilateral lung tissue irradiated with 20 Gy (strata: ≤30% vs. >30%); Heart Dmean, mean dose delivered to heart (strata: ≤5 Gy vs. >5 Gy).
  3. *Analyzed for patients with left-sided radiation plans.
  4. #No patients with implant breast reconstruction received >5 Gy to heart.
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Radiation Oncology

ISSN: 1748-717X

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