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Table 4 Univariate analysis of lung and heart dosimetry and possible confounders in patients with chest wall only and chest wall plus lymph nodes irradiation (n = 818)

From: No difference in dose distribution in organs at risk in postmastectomy radiotherapy with or without breast implant reconstruction

  

Chest wall, n = 242

Chest wall plus lymph nodes, n = 576

  

Lung V20Gy

Heart D mean*

Lung V20Gy

Heart D mean*

Confounders

 

≤30%

>30%

OR (95%CI)

P-value

≤5Gy

>5Gy

OR (95%CI)

P-value

≤30%

>30%

OR (95%CI)

P-value

≤5Gy

>5Gy

OR (95%CI)

P-value

Reconstruction

IBR-

155

7

  

75

8

  

293

201

  

236

36

  
 

IBR+

75

5

1.5 (0.5 to 4.8)

0.52

35

0

-#

-#

56

26

0.7 (0.4 to 1.1)

0.13

31

6

1.3 (0.5 to 3.3)

 

Side

Right

118

6

  

-

-

  

165

102

  

-

-

  
 

Left

112

6

1.1 (0.3 to 3.4)

0.93

110

8

-

-

184

125

1.1 (0.8 to 1.5)

0.58

267

42

-

-

Chest wall index

CWi ≤ med

118

7

  

57

7

  

222

119

  

162

26

  
 

CWi > med

112

5

0.8 (0.2 to 2.4)

0.64

53

1

0.2 (0 to 1.3)

0.09

127

108

1.6 (1.1 to 2.2)

0.008

105

16

0.9 (0.5 to 1.9)

0.88

  1. CTV indicates clinical target volume; IBR, immediate breast reconstruction; CWi, chest wall index; med, median.
  2. Lung V20Gy, volume of lung tissue irradiated with 20 Gy (strata: ≤30% vs. >30%); Heart D mean, mean dose delivered to heart (strata: ≤5 Gy vs. >5 Gy);
  3. CTV V95%, percent of clinical target volume irradiated with ≤95% of isodose (strata: ≤median vs. >median).
  4. *Analyzed for patient with left-sided radiation plans (n = 118/242 and n = 309/576).
  5. #No patients with implant breast reconstruction received >5 Gy to heart.
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Radiation Oncology

ISSN: 1748-717X

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