Table 1 Hippocampal dose-volume constraints and achieved doses in representative HA WBRT planning studies

Gutierrez, 2007[47]

WBRT

HT

10

15 × 2.15 Gy

6 Gy

-

5.86 Gy₂

5.34 Gy₂

2

Gondi, 2010[37]

WBRT

HT

5

10 × 3.0 Gy

6 Gy

3 Gy ≤ 20%

12.8 Gy

-

5.5 Gy

2

LINAC

11 Gy

9 Gy ≤ 40%

15.3 Gy

7.8 Gy

2

Hsu, 2010[50]

WBRT + SIB

LINAC

10

15 × 2.15 Gy (SIB á 4.2 Gy)

-

D_mean < 6 Gy₂

-

5.23 Gy₂

-

2

Marsh, 2010[51]

PCI

HT

11

15 × 2.0 Gy

15 Gy

-

12.5 Gy

-

-

WBRT

11

14 × 2.5 Gy

15 Gy

14.3 Gy

Marsh, 2010[52]

PCI

HT

10

15 × 2.0 Gy

-

11.5 Gy

-

-

WBRT

10

14 × 2.5 Gy

-

-

-

11.8 Gy

-

-

Van Kesteren, 2012[39]

WBRT

LINAC 3D-CRT

10

12 × 2.5 Gy

13.5 Gy

6Gy

-

10

Nevelsky, 2013[46]

WBRT

LINAC IMRT

10

10 × 3.0 Gy

16 Gy

D_100% < 9 Gy

14.35 Gy

-

-

-

Awad, 2013[49]

WBRT + SIB

VMAT RA

30

5-15fx

-

32.2 Gy

20.4 Gy

21.9 Gy

-

Prokic, 2013[48]

WBRT + SIB

VMAT RA

10

12 × 2.5 Gy BM 12 × 4.25

-

12.33 Gy (D_2%)

7.55 Gy

7.15 Gy

H 2

BM 10

WBRT + FSRT

VMAT RA

10

12 × 2.5 Gy + FSRT 2 × 9 Gy

-

15.82 Gy (D_2%)

9.8 Gy

9.34 Gy

H 2

BM 10