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Table 3 Comparative dosimetry after planning based on lymphoscintigraphy (LS) or international guidelines (IG) volumes

From: SPECT/CT lymphoscintigraphy of sentinel node(s) for superselective prophylactic irradiation of the neck in cN0 head and neck cancer patients: a prospective phase I feasibility study

 

LS

IG

P-value

Nervous structures

   

Spinal cord D2% (Gy)

41.7

43.4

0.083

Brainstem D2% (Gy)

4.2

23.7

0.013

Salivary glands

   

Left parotid Dmean (Gy)

4.2

25.0

0.006

Right parotid Dmean (Gy)

10.9

25.4

0.006

Left submand Dmean (Gy)

22.6

46.9

0.009

Right submand Dmean (Gy)

27.4

42.7

0.014

Swallowing muscles

   

SPC Dmean (Gy)

22.3

41.2

0.009

MPC Dmean (Gy)

45.1

54.6

0.041

LPC Dmean (Gy)

55.4

56.4

0.154

UES Dmean (Gy)

39.8

54.3

0.006

Oesophagus Dmean (Gy)

9.6

43.6

0.006

Oral cavity Dmean (Gy)

15.0

20.3

0.024

RVR volume at D proph (cc)

63.7

108.4

0.006

  1. D2% = dose received by 2% of the volume; Dmean = mean dose; Submand = submandibular gland; SPC = superior pharyngeal constrictor muscle; MPC = middle pharyngeal constrictor muscle; LPC = low pharyngeal constrictor muscle; UES = upper oesophageal sphincter.
  2. Median D2% for nervous structures; median Dmean for salivary glands, swallowing structures and oral cavity and median volume of remaining volume at risk (RVR) treated at prophylactic dose (Dproph) are reported. P-values for statistical comparison of differences are reported in last column; significant values are written in bold.