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Table 3 Univariateanalysis of V3G-V5G and V3-V5

From: Whole brain radiotherapy plus simultaneous in-field boost with image guided intensity-modulated radiotherapy for brain metastases of non-small cell lung cancer

 

V3G (cc)

V4G (cc)

V5G (cc)

V3 (%)

V4 (%)

V5 (%)

 

Mean ± SD

p

Mean ± SD

p

Mean ± SD

p

Mean ± SD

p

Mean ± SD

p

Mean ± SD

p

leukoencephalopathy

            

  Grade 0-1

204.94 ± 150.85

0.288

77.94 ± 67.47

0.316

34.12 ± 30.99

0.574

4.66 ± 3.40

0.102

1.77 ± 1.52

0.334

0.78 ± 0.71

0.609

  Grade 2

128.60 ± 80.62

 

51.08 ± 49.53

 

27.14 ± 24.85

 

3.00 ± 1.81

 

1.18 ± 1.12

 

0.63 ± 0.57

 

Number of lesions

            

  <3

126.05 ± 115.60

0.017

39.06 ± 44.83

0.004

18.65 ± 17.00

0.010

2.94 ± 2.55

0.020

0.91 ± 0.98

0.004

0.44 ± 0.39

0.013

  ≥3

245.84 ± 136.82

 

104.24 ± 64.15

 

46.70 ± 32.90

 

5.57 ± 3.14

 

2.36 ± 1.47

 

1.05 ± 0.76

 

Maximum lesion volume

            

  <3 cc

94.13 ± 67.73

0.004

35.77 ± 27.52

0.006

15.35 ± 7.55

0.003

2.20 ± 1.42

0.001

0.83 ± 0.61

0.006

0.36 ± 0.17

0.004

  ≥3 cc

238.73 ± 143.95

 

91.77 ± 70.05

 

42.49 ± 32.74

 

5.43 ± 3.24

 

2.08 ± 1.58

 

0.97 ± 0.75

 

Total volume of lesions

            

  <7 cc

108.74 ± 76.57

0.002

35.82 ± 31.48

0.002

15.43 ± 11.06

0.001

2.55 ± 1.75

0.003

0.83 ± 0.70

0.002

0.36 ± 0.25

0.002

  ≥7 cc

264.39 ± 145.93

 

107.71 ± 68.56

 

50.15 ± 30.07

 

5.98 ± 3.30

 

2.44 ± 1.56

 

1.14 ± 0.74

 

Total

183.87 ± 138.15

 

70.53 ± 63.36

 

32.19 ± 29.16

 

4.21 ± 3.10

 

1.61 ± 1.43

 

0.74 ± 0.67

 
  1. Abbreviations: VXG =. The volume of normal brain tissue receiving at least XGy per fraction during the SIB; VX =. The percentage volume of normal brain receiving at least XGy per fraction during the SIB; cc = cubic centimeter.