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Table 3 Univariateanalysis of V3G-V5G and V3-V5

From: Whole brain radiotherapy plus simultaneous in-field boost with image guided intensity-modulated radiotherapy for brain metastases of non-small cell lung cancer

  V3G (cc) V4G (cc) V5G (cc) V3 (%) V4 (%) V5 (%)
  Mean ± SD p Mean ± SD p Mean ± SD p Mean ± SD p Mean ± SD p Mean ± SD p
leukoencephalopathy             
  Grade 0-1 204.94 ± 150.85 0.288 77.94 ± 67.47 0.316 34.12 ± 30.99 0.574 4.66 ± 3.40 0.102 1.77 ± 1.52 0.334 0.78 ± 0.71 0.609
  Grade 2 128.60 ± 80.62   51.08 ± 49.53   27.14 ± 24.85   3.00 ± 1.81   1.18 ± 1.12   0.63 ± 0.57  
Number of lesions             
  <3 126.05 ± 115.60 0.017 39.06 ± 44.83 0.004 18.65 ± 17.00 0.010 2.94 ± 2.55 0.020 0.91 ± 0.98 0.004 0.44 ± 0.39 0.013
  ≥3 245.84 ± 136.82   104.24 ± 64.15   46.70 ± 32.90   5.57 ± 3.14   2.36 ± 1.47   1.05 ± 0.76  
Maximum lesion volume             
  <3 cc 94.13 ± 67.73 0.004 35.77 ± 27.52 0.006 15.35 ± 7.55 0.003 2.20 ± 1.42 0.001 0.83 ± 0.61 0.006 0.36 ± 0.17 0.004
  ≥3 cc 238.73 ± 143.95   91.77 ± 70.05   42.49 ± 32.74   5.43 ± 3.24   2.08 ± 1.58   0.97 ± 0.75  
Total volume of lesions             
  <7 cc 108.74 ± 76.57 0.002 35.82 ± 31.48 0.002 15.43 ± 11.06 0.001 2.55 ± 1.75 0.003 0.83 ± 0.70 0.002 0.36 ± 0.25 0.002
  ≥7 cc 264.39 ± 145.93   107.71 ± 68.56   50.15 ± 30.07   5.98 ± 3.30   2.44 ± 1.56   1.14 ± 0.74  
Total 183.87 ± 138.15   70.53 ± 63.36   32.19 ± 29.16   4.21 ± 3.10   1.61 ± 1.43   0.74 ± 0.67  
  1. Abbreviations: VXG =. The volume of normal brain tissue receiving at least XGy per fraction during the SIB; VX =. The percentage volume of normal brain receiving at least XGy per fraction during the SIB; cc = cubic centimeter.