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Table 2 Univariate and multivariate analysis of IC-PFS, median survival and incidence of grade 2 leukoencephalopathy

From: Whole brain radiotherapy plus simultaneous in-field boost with image guided intensity-modulated radiotherapy for brain metastases of non-small cell lung cancer

  IC-PFS (m) Median Univariate p-value Multivariate p-value MS(m) Univariate p-value Multivariate p-value Leukoencephalopathy No. of patients (%) Univariate p-value Multivariate p-value
Gender          
  Male 6 0.020 0.869 7 0.019 0.983 3/20 (15.5) 0.024 0.562
  Female 18    18    5/9 (55.6%)   
Age (years)          
  ≥60 8 0.628   8 0.719   5/18 (27.8) 0.794  
  <60 12    12    3/11 (27.3)   
KPS scores          
  ≥70 12 0.251   12 0.223   5/19 (26.3) 0.833  
  <70 3    4.4    3/10(30)   
Pathology          
  Adenocarcinoma 14 0.015 0.519 14 0.011 0.553 6/13 (46.2) 0.044 0.084
  Non-adenocarcinoma 3    4.4    2/16 (12.5)   
RPA class          
  2 12 0.266   12 0.185   5/19 (26.3) 0.833  
  3 3    4.4    3/10 (30.0%)   
GPA scores          
  0-1 6 0.331   7 0.188   4/13 (30.8) 0.730  
  1.5-3.5 14    14    4/16 (25%)   
SIR scores          
  ≤5 3 0.001 0.044 4.4 <0.001 0.021 5/13 (38.5) 0.238  
  >5 14    14    3/16 (18.75)   
History of EGFR-TKI treatment          
  Yes 16 0.026 0.035 18 0.022 0.040 7/11 (63.6) 0.001 0.010
  No 6    7    1/18 (5.6)   
Number of lesions          
  <3 14 0.005 0.036 14 0.007 0.048 6/15 (40.0) 0.122  
  ≥3 3    6    2/14 (14.3)   
Maximum lesion volume          
  <3 cc 14 0.209   14 0.081   4/12 (33.3) 0.561  
  ≥3 cc 4.4    6    4/17 (23.5)   
Total volume of lesions          
  <7 cc 14 0.032 0.232 14 0.037 0.256 5/15 (33.3) 0.474  
  ≥7 cc 3    6    3/14 (21.4)   
Total 10    10    8/29 (27.6)   
  1. Abbreviations: IC-PFS = intracranial progression-free survival; MS = median survival; m = month; RPA = recursive partitioning analysis; GPA = graded prognostic assessment; SIR = score index for radiosurgery in brain metastases; EGFR-TKI = epidermal growth factor receptor- tyrosine kinase inhibitor.