| |
IC-PFS (m) Median
|
Univariate p-value
|
Multivariate p-value
|
MS(m)
|
Univariate p-value
|
Multivariate p-value
|
Leukoencephalopathy No. of patients (%)
|
Univariate p-value
|
Multivariate p-value
|
|---|
|
Gender
| | | | | | | | | |
|
Male
|
6
|
0.020
|
0.869
|
7
|
0.019
|
0.983
|
3/20 (15.5)
|
0.024
|
0.562
|
|
Female
|
18
| | |
18
| | |
5/9 (55.6%)
| | |
|
Age (years)
| | | | | | | | | |
|
≥60
|
8
|
0.628
| |
8
|
0.719
| |
5/18 (27.8)
|
0.794
| |
|
<60
|
12
| | |
12
| | |
3/11 (27.3)
| | |
|
KPS scores
| | | | | | | | | |
|
≥70
|
12
|
0.251
| |
12
|
0.223
| |
5/19 (26.3)
|
0.833
| |
|
<70
|
3
| | |
4.4
| | |
3/10(30)
| | |
|
Pathology
| | | | | | | | | |
|
Adenocarcinoma
|
14
|
0.015
|
0.519
|
14
|
0.011
|
0.553
|
6/13 (46.2)
|
0.044
|
0.084
|
|
Non-adenocarcinoma
|
3
| | |
4.4
| | |
2/16 (12.5)
| | |
|
RPA class
| | | | | | | | | |
|
2
|
12
|
0.266
| |
12
|
0.185
| |
5/19 (26.3)
|
0.833
| |
|
3
|
3
| | |
4.4
| | |
3/10 (30.0%)
| | |
|
GPA scores
| | | | | | | | | |
|
0-1
|
6
|
0.331
| |
7
|
0.188
| |
4/13 (30.8)
|
0.730
| |
|
1.5-3.5
|
14
| | |
14
| | |
4/16 (25%)
| | |
|
SIR scores
| | | | | | | | | |
|
≤5
|
3
|
0.001
|
0.044
|
4.4
|
<0.001
|
0.021
|
5/13 (38.5)
|
0.238
| |
|
>5
|
14
| | |
14
| | |
3/16 (18.75)
| | |
|
History of EGFR-TKI treatment
| | | | | | | | | |
|
Yes
|
16
|
0.026
|
0.035
|
18
|
0.022
|
0.040
|
7/11 (63.6)
|
0.001
|
0.010
|
|
No
|
6
| | |
7
| | |
1/18 (5.6)
| | |
|
Number of lesions
| | | | | | | | | |
|
<3
|
14
|
0.005
|
0.036
|
14
|
0.007
|
0.048
|
6/15 (40.0)
|
0.122
| |
|
≥3
|
3
| | |
6
| | |
2/14 (14.3)
| | |
|
Maximum lesion volume
| | | | | | | | | |
|
<3 cc
|
14
|
0.209
| |
14
|
0.081
| |
4/12 (33.3)
|
0.561
| |
|
≥3 cc
|
4.4
| | |
6
| | |
4/17 (23.5)
| | |
|
Total volume of lesions
| | | | | | | | | |
|
<7 cc
|
14
|
0.032
|
0.232
|
14
|
0.037
|
0.256
|
5/15 (33.3)
|
0.474
| |
|
≥7 cc
|
3
| | |
6
| | |
3/14 (21.4)
| | |
|
Total
|
10
| | |
10
| | |
8/29 (27.6)
| | |
- Abbreviations: IC-PFS = intracranial progression-free survival; MS = median survival; m = month; RPA = recursive partitioning analysis; GPA = graded prognostic assessment; SIR = score index for radiosurgery in brain metastases; EGFR-TKI = epidermal growth factor receptor- tyrosine kinase inhibitor.
