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Figure 1 | Radiation Oncology

Figure 1

From: Integrating microRNA and mRNA expression profiles in response to radiation-induced injury in rat lung

Figure 1

Photomicrographs illustrating the histological response of lungs of rats irradiated with 20 Gy after a post-exposure period of approximately 26 weeks (H&E, 100X). Gross examination of lungs at autopsy: (A) normal lung in non-irradiated rat; (B) 3 week; (C) 12 week; (D) 26 week; (E) Normal lung parenchyma and vessels in controls. (F) The third week after radiation shows the visibility of interstitial inflammatory edema and intra-alveolar hemorrhage; (G) The 12th week after radiation shows diffuse increase in alveolar septal thickening, vascular wall thickening and sclerosis, with focal necrosis and subsequent organization; (H) The 26th week after radiation shows fibroblast proliferation and increased collagen accumulation in the interstitial, as well as in the intra-alveolar space, and widespread loss of tissue architecture. (The right lung are indicated with arrowheads).

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