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Table 3 Median radiation doses to cavernous sinus, optic nerves and chiasm in patients treated with multi-fraction SRS (5 × 5 Gy)

From: Fractionated stereotactic radiosurgery for patients with skull base metastases from systemic cancer involving the anterior visual pathway

Site Median Maximum Organ at risk Volume (cm3) Volume (cm3)
  dose dose volume receiving receiving
  (Gy) (Gy) (cm3) a dose > 25.0 Gy a dose > 27.5 Gy
Cavernous sinus 18.5 29 1.9 (1.44-2.52) 1.7 (1.41-2.4) 0.52 (0.2-1.9)
Optic nerve 13.5 28.5 0.93 (0.71-1.26) 0.08 (0.01-0.5) 0.026 (0.005-0.08)
Optic chiasm 5.5 (12*) 28.5 0.48 (0.33-0.71) 0.13 (0.03-0.28)* 0.022 (0.01-0.06)*
  1. *In 18 patients receiving a total dose to the optic chiasm >25 Gy.