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Table 2 Univariate and multivariate analysis of prognostic factors for overall survival and distant failure

From: Fractionated stereotactic radiosurgery for patients with skull base metastases from systemic cancer involving the anterior visual pathway

Variable Median Univariate Multivariate analysis
  Survival time (months) Analysis P value Hazard ratio (95% CI) P value
Overall survival     
Sex, male vs female male (16.1); female (13.5) 0.1   
Age (years), < 65 vs ≥ 65 < 65 (15.0); ≥ 65 (11.5) 0.1   
KPS, ≤ 70 vs >70 ≤ 70 (11.5); >70 (20.3) 0.001 0.30 (0.1-0.68) 0.01
Primary tumor, breast cancer vs others breast cancer (13.0); others (15.5) 0.2   
Extracranial metastases, absent vs present absent (22.5); present (11.2) 0.0001 0.10 (0.05-0.40) 0.001
Number of metastases, 1 vs > 1 1 met (15.5); >1 met (13.2) 0.3   
Distant brain failure     
Sex, male vs female male (16.1); female (13.5) 0.9   
Age (years), < 65 vs ≥ 65 < 65 (12.0); ≥ 65 (10.0) 0.2   
KPS, ≤ 70 vs >70 ≤ 70 (8.0); >70 (16.0) 0.03 0.36 (0.16-1.27) 0.1
Primary tumor, breast cancer vs others breast cancer (10.0); others (14.0) 0.1   
Extracranial metastases, absent vs present absent (18.0); present (8.0) 0.002 0.18 (0.07-0.64) 0.01
Number of metastases, 1 vs > 1 1 met (16.0); > 1 met (10.0) 0.1   
  1. KPS, Karnofsky Performance Status.