Salvage brachytherapy in prostate local recurrence after radiation therapy: predicting factors for control and toxicity

Table 4 Salvage brachytherapy series after local failure of radiation therapy for prostate cancer

Study, year	Salvage brachytherapy doses	N	Pre-salvage PSA (ng/ml)	Median f/u (mo)	Outcome	Grade 3/4 toxicity
Grado et al., 1999[4]	LDR 145 Gy	49	5.6	64	34% 5-y bDFS^a	16%
Grado et al., 1999[4]	LDR 145 Gy	49	5.6	64	56% 5-y bDFS^b	16%
Beyer et al., 1999[3]	LDR 120 Gy ¹²⁵I	17	2.2	62	53% 5-y FFSR^c	NR
Beyer et al., 1999[3]	90 Gy ¹⁰³P	17	2.2	62	53% 5-y FFSR^c	NR
Wong et al., 2006[5]	LDR 126 Gy	17	4.7	44	75% 4-y FfbF^c	47%
Allen et al., 2007[6]	LDR 97 Gy^d	12	3.8	45	63% 5-y FfbF^c	0%
Chen et al., 2013[9]	HDR 36 Gy	52	9.3	59.6	51% 5-y FfbF^e	2%
Nguyen et al., 2007[7]	LDR 137 Gy^f	25	9.46	46	70% 4-y FfbF^e	30%
Lee et al., 2008[8]	LDR 90 Gy^g	21	3.8	36	38% 5-y FfbF^c	0%
Aaronson et al., 2009[10]	LDR 144 Gy	24	3.4	30	89% 3-y FfbF^e	4%
Burri et al., 2010[11]	LDR 135 Gy ¹²⁵I	37	5.6	86	65% 5-y FFbF	11%
Burri et al., 2010[11]	110 Gy ¹⁰³P	37	5.6	86	54% 10-y FfbF^e	11%
Current series, 2013	HDR (BED_{2 Gy}) 125–419 Gy	56	5	48	77% 5-y FFbF^e	HDR GU/GI
	HDR (BED_{2 Gy}) 125–419 Gy					G3....... 21%/2%
	LDR 145 Gy					LDR GU/GI
	LDR 145 Gy					G3..... 24%/0%
						G4..... 0%/ 2.7%

LDR = low dose rate; HDR = high dose rate; bDFS = biochemical disease-free survival; FFSR = freedom from second relapse; NR = not reported; GU = genitourinary; GI = gastrointestinal; G3 = grade 3; G4 = grade 4.
^aFailure defined as two PSA rises above nadir.
^bNadir psa < 0.5 ng/ml.
^cFailure defined as ASTRO definition.
^dMedian dose.
^eFailure defined as Phoenix definition.
^fMedian minimum peripheral dose.
^gMinimum peripheral dose.

ISSN: 1748-717X