Significance of an increase in the Child-Pugh score after radiotherapy in patients with unresectable hepatocellular carcinoma

Table 5 Clinical and tumor characteristics assosiated with an increase in CP score

Variables	No toxicity	Toxicity	p value
Gender
Male	45	35	0.475
Female	11	12
Age
Median	60	57	0.142
Range	21-80	40-80
ECOG PS
0	18	20	0.275
1	38	27
Hepatitis
B	40	33	0.892
Others	16	14
Liver cirrhosis
No	19	13	0.493
Yes	37	34
PVTT
No	30	15	0.027
Yes	26	32
AFP
≤400	40	27	0.138
>400	16	20
Pretreatment CP class
A	52	39	0.120
B	4	8
PTV
≤225 cm³	42	18	<0.001
>225 cm³	14	29
BED
≤70 Gy	22	27	0.066
>70 Gy	34	20
Hypofractionation
<4 Gy per fraction	39	24	0.054
≥4 Gy per fraction	17	23

Abbreviations: HR hazard ratio, CI confidence interval, ECOG PS Eastern Cooperative Oncology Group performance status, PVTT portal vein tumor thrombosis, AFP alpha-fetoprotein, CP Child-Pugh, PTV planning target volume, BED biologically effective dose.

ISSN: 1748-717X