Table 3 Factors associated with LPFS, RFS and OS on univariate analysis
From: Toxicity and outcomes of thoracic re-irradiation using stereotactic body radiation therapy (SBRT)
LPFS | RFS | OS | ||||
|---|---|---|---|---|---|---|
Characteristic | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value |
Type of Cancer | ||||||
Recurrent/metastasis | Reference | Reference | Reference | |||
Second Primary | 0.26 (0.07, 1.04) | 0.06 | 0.16 (0.05, 0.51) | 0.002 | 0.37 (0.14, 0.99) | 0.05 |
Overlap with prior RT field | ||||||
Yes | Reference | Reference | Reference | |||
No | 0.11 ( 0.01,0.88) | 0.04 | 0.52 (0.19, 1.39) | 0.19 | 0.69 (0.27, 1.77) | 0.44 |
BED10 of SBRT | ||||||
<100 Gy | Reference | Reference | Reference | |||
≥100 Gy | 0.18 (0.04, 0.90) | 0.04 | 0.31 (0.10, 0.93) | 0.038 | 0.25 (0.08, 0.76) | 0.014 |
Time from prior RT to SBRT | ||||||
≤36 months | Reference | Reference | Reference | |||
>36 months | 0.25 (0.06,0.99) | 0.05 | 0.37 (0.14, 0.97) | 0.04 | 0.63 (0.25, 1.56) | 0.32 |
PTV volume | ||||||
>75 cc | Reference | Reference | Reference | |||
16-75 cc | 0.09 (0.01,0.79) | 0.03 | 0.30 (0.10, 0.90) | 0.03 | 0.27 (0.10, 0.71) | 0.008 |
KPS | ||||||
<80 | Reference | Reference | Reference | |||
≥80 | 0.16 (0.03, 0.85) | 0.03 | 0.43 (0.10, 1.95) | 0.28 | 0.11 (0.03, 0.36) | 0.0003 |