From: Radiosensitivity in breast cancer assessed by the histone γ-H2AX and 53BP1 foci
Subjecta | Age (years) | Sex | Clinical status with respect to cancer, skin reaction to RTb | 0 Gy | 0.5 Gy, 30’ | 0.5 Gy, 24 h | 2 Gy, 24 h | 72 h after 5 clinical fractions |
---|---|---|---|---|---|---|---|---|
Apparently healthy donors | ||||||||
N-3 | 29 | F | n.d. | 0.71 | 2.47 | 0.99 | 1.47 | |
N-4 | 58 | F | n.d. | 0.68 | 2.83 | 0.96 | 1.37 | |
N-5 | 58 | F | n.d. | 0.41 | 2.65 | 1.16 | 1.25 | |
N-6 | 65 | F | n.d. | 0.35 | 2.48 | 1.07 | 1.73 | |
N-7 | 56 | F | n.d. | 0.53 | 2.26 | 0.66 | 0.76 | |
N-8 | 48 | F | n.d. | 0.38 | 2.32 | 0.98 | 1.36 | |
N-9 | 41 | F | n.d. | 0.32 | 2.10 | 0.96 | 1.04 | |
N-10 | 44 | F | n.d. | 0.50 | 2.46 | 0.79 | 1.02 | |
N-11 | 48 | F | n.d. | 0.48 | 2.60 | 0.81 | 1.20 | |
N-12 | 43 | F | n.d. | 0.38 | 2.42 | 0.67 | 0.80 | |
Mean | 45 | 0.47 | 2.46 | 0.91 | 1.20 | |||
± SD | 12 | 0.13 | 0.20 | 0.16 | 0.29 | |||
Breast cancer patients | ||||||||
BC-01 | 59 | F | BC, grade 3 | 0.13 | 0.85 | n.d. | 1.84 | 1.73 |
BC-04 | 73 | F | BC, grade 3 | 0.15 | 1.24 | n.d. | 2.61 | 1.68 |
BC-12 | 61 | F | BC, grade 3 | 0.11 | 1.19 | n.d. | 2.18 | 0.95 |
BC-13 | 55 | F | BC, grade 3 | 0.35 | 2.47 | n.d. | 2.86 | 1.23 |
BC-33 | 42 | F | BC, grade 3 | 0.35 | 0.87 | n.d. | 2.78 | 1.60 |
BC-39 | 55 | F | BC, grade 1 | 0.32 | 2.56 | 0.75 | 1.41 | 0.90 |
BC-40 | 77 | F | BC, grade 2 | 0.61 | 2.43 | 0.62 | 0.61 | 0.78 |
BC-41 | 54 | F | BC, grade 1 | 0.97 | 2.36 | 1.11 | 1.34 | 0.91 |
BC-42 | 49 | F | BC, grade 1 | 0.19 | 2.48 | 0.76 | 1.68 | 0.80 |
BC-43 | 62 | F | BC, grade 2 | 0.33 | 1.99 | 0.92 | 1.58 | 0.42 |
BC-44 | 59 | F | BC, grade 1 | 0.24 | 2.08 | 1.25 | 2.16 | 0.58 |
BC-45 | 51 | F | BC, grade 1 | 0.20 | 1.73 | 1.20 | 2.12 | 0.77 |
BC-46 | 62 | F | BC, grade 1 | 0.33 | 2.73 | 1.34 | 0.56 | 0.74 |
BC-47 | 30 | F | BC, grade 2 | 0.26 | 2.57 | 1.38 | 0.98 | 0.65 |
BC-48 | 71 | F | BC, grade 2 | 0.79 | 3.34 | 1.16 | 1.96 | 0.93 |
BC-49 | 46 | F | BC, grade 2 | 0.49 | 3.19 | 1.19 | 1.84 | 0.62 |
BC-50 | 48 | F | BC, grade 3 | 0.68 | 3.29 | 0.88 | 1.39 | 0.68 |
BC-51 | 57 | F | BC, grade 1 | 0.71 | 2.82 | 0.93 | 1.43 | 0.50 |
BC-52 | 62 | F | BC, grade 2 | 0.66 | 2.48 | 0.87 | 1.50 | 0.59 |
BC-53 | 68 | F | BC, grade 2 | 0.98 | 2.81 | 0.84 | 1.37 | 0.55 |
BC-54 | 37 | F | BC, grade 1 | 0.65 | 2.29 | 0.84 | 1.49 | 0.95 |
BC-55 | 67 | F | BC, grade 1 | 0.73 | 2.35 | 0.89 | 1.50 | 0.71 |
BC-57 | 55 | F | BC, grade 1 | 0.86 | 3.40 | 0.89 | 2.04 | 0.69 |
BC-58 | 62 | F | BC, grade 1 | 0.52 | 3.25 | 0.95 | 2.05 | 0.57 |
BC-59 | 55 | F | BC, grade 1 | 0.45 | 2.69 | 0.82 | 1.62 | 0.88 |
BC-60 | 65 | F | BC, grade 2 | 0.65 | 2.86 | 0.97 | 1.61 | 0.49 |
BC-61 | 54 | F | BC, grade 2 | 0.54 | 2.66 | 0.88 | 1.63 | 0.96 |
BC-62 | 53 | F | BC, grade 2 | 0.49 | 2.65 | 0.77 | 1.37 | 0.72 |
BC-63 | 69 | F | BC, grade 1 | 0.62 | 2.73 | 1.05 | 1.81 | 0.58 |
BC-64 | 81 | F | BC, grade 1 | 0.6 | 2.62 | 0.84 | 1.37 | 0.47 |
BC-65 | 38 | F | BC, grade 2 | 0.58 | 2.35 | 0.95 | 1.70 | 0.87 |
BC-66 | 77 | F | BC, grade 1 | 0.46 | 2.46 | 0.83 | 1.44 | 0.57 |
BC-67 | 48 | F | BC, grade 1 | 0.43 | 1.87 | 0.86 | 1.52 | 0.66 |
BC-68 | 49 | F | BC, grade 2 | 0.42 | 2.49 | 0.65 | 1.73 | 0.73 |
BC-69 | 51 | F | BC, grade 1 | 0.41 | 2.00 | 0.84 | 1.70 | 0.49 |
Mean | 57 | 0.49 | 2.40 | 0.94 | 1.70 | 0.80 | ||
± SD | 12 | 0.23 | 0.63 | 0.19 | 0.49 | 0.32 |