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Table 5 Literature review of IORT for cervical cancer

From: Intraoperative Electron Beam Radiotherapy (IOERT) in the management of locally advanced or recurrent cervical cancer

Series

Date

Patients (n)

Advanced primary or recurrent

IORT modality

Median IORT dose (Gy)

Crude LRR

Median survival (mos)

OS

Hicks et al [18].

1993

13

Recurrent

Orthovoltage

15

7/13

7

-

Konski et al [24].

1993

8

Primary

IOERT

20

7/8

27

-

  

5

Recurrent

IOERT

20

-

9

-

Gerard et al [17].

1994

20

Primary

IOERT

-

4/20

-

75% at 18 mos

  

34

Recurrent

IOERT

-

6/34

-

32% at 4 yrs

Stelzer et al [23].

1995

22

Recurrent

IOERT

22

10/22

26

43% at 5 yrs (CSS)

Mahé et al [19].

1996

70

Recurrent

IOERT

19

50/67

11

8% at 3 yrs

del Carmen et al [14].

2000

5

Recurrent

IOERT

15

2/5

-

-

Gemignani et al [16].

2001

9

Recurrent

HDR-BT

14

-

-

54% at 3 yrs

Martinez-Monge et al [20].

2001

31

Primary

IOERT

12

6/31

-

58% at 10 yrs

  

36

Recurrent

IOERT

15

18/36

-

14% at 10 yrs

Roth et al [21].

2003

1

Recurrent

HDR-BT

15

0/1

20

-

Tran et al [22].

2007

17

Recurrent

Orthovoltage

11.5

-

-

47% at 5 yrs (CSS)

Current series

2012

13

Primary

IOERT

12.5

4/13

13

29% at 3 yrs

  

73

Recurrent

IOERT

17.5

33/73

17

25% at 3 yrs

  1. Abbreviations: IORT = intraoperative radiotherapy; LRR = locoregional recurrence; OS = overall survival; IOERT = intraoperative electron beam radiotherapy; CSS = cause-specific survival; HDR-BT = high-dose rate brachytherapy.