Table 1 Patient and disease characteristics (n = 555)
Characteristic | Patients (%) |
|---|---|
Age (median, 69 y) | |
< 70 y | 288 (51.9) |
≥ 70 y | 267 (48.1) |
Gender | |
Female | 183 (33.0) |
Male | 372 (67.0) |
Pathologic type, verified | |
Yes, adenocarcinoma | 417 (75.1) |
Yes, other | 5 (0.9) |
No | 133 (24.0) |
Ultrasonography (before RT) | |
Yes | 451 (81.3) |
No | 21 (3.8) |
Unknown | 83 (14.9) |
CT (before RT) | |
Yes | 515 (92.8) |
No | 5 (0.9) |
Unknown | 35 (6.3) |
MRCP (before RT) | |
Yes | 324 (58.4) |
No | 152 (27.4) |
Unknown | 79 (14.2) |
PTCD | |
Yes | 242 (43.6) |
No | 151 (27.2) |
Unknown | 162 (29.2) |
Primary site | |
Intrahepatic bile duct | 71 (12.8) |
Gallbladder | 42 (7.6) |
Extrahepatic bile duct | 439 (79.1) |
Perihilar | 278 (50.0) |
Distal | 144 (25.9) |
Unknown | 17 (3.1) |
Ampulla of Vater | 3 (0.5) |
Maximal tumor size (Median, 4.0 cm) | |
< 4.0 cm | 195 (35.1) |
≥ 4.0 cm | 198 (35.7) |
Unknown | 162 (29.2) |
Tumor emboli | |
Yes | 32 (5.8) |
No | 292 (52.6) |
Unknown | 231 (41.6) |
ECOG performance status | |
0 | 223 (40.2) |
1 | 226 (40.7) |
2 | 77 (13.8) |
3 | 17 (3.1) |
4 | 1 (0.2) |
Unknown | 11 (2.0) |
Jaundice | |
Yes | 355 (64.0) |
No or unknown | 200 (36.0) |
CA19-9 (U/mL) | |
< 37 | 102 (18.4) |
37-1,000 | 253 (45.6) |
≥ 1,000 | 81 (14.6) |
Unknown | 119 (21.4) |
CEA (ng/ml) | |
< 5 | 300 (54.1) |
5-10 | 63 (11.3) |
≥ 10 | 49 (8.8) |
Unknown | 143 (25.8) |
Alcohol consumption | |
Yes | 193 (34.8) |
No | 223 (40.2) |
Unknown | 139 (25.0) |
Smoking | |
Yes | 175 (31.5) |
No | 239 (43.1) |
Unknown | 141 (25.4) |
Diabetes mellitus | |
Yes | 75 (13.5) |
No | 383 (69.0) |
Unknown | 97 (17.5) |
Clinical T stage | |
TX | 11 (2.0) |
T1 | 41 (7.4) |
T2 | 147 (26.4) |
T3 | 183 (33.0) |
T4 | 112 (20.2) |
Unknown | 61 (11.0) |
Clinical N stage | |
N0 | 310 (55.9) |
N1 | 165 (29.7) |
Unknown | 80 (14.4) |
Clinical stage | |
I | 96 (17.3) |
II | 202 (36.4) |
III | 146 (26.3) |
IV | 25 (4.5) |
Unknown | 86 (15.5) |
Resectable at diagnosis | |
Yes | 254 (45.8) |
No | 288 (51.9) |
Unknown | 13 (2.3) |
Investigational protocol | |
Yes | 0 (0) |
No | 555 (100) |