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Table 3 SBRT reirradiation for head and neck cancer

From: Stereotactic body radiation therapy in the re-irradiation situation – a review

Clinical trial Voynov et al. 2006 Heron et al. 2009 Unger et al. 2010 Roh et al. 2009 Ozyigit et al. 2009 Vargo et al. 2012
n 22 25 65 36 24 34
Initial therapy dose median BED10 97.8 Gy (70.1 – 190.3 Gy) median, 64.7 Gy median 67 Gy (32–120 Gy) median, 70.2 Gy (39.6 – 134.4 Gy) median, 70 Gy (48–70 Gy) median 61.2 Gy (42–157 Gy).
Interval n/s 13 months (range, 5–94 months) 26 months (range, 2–318 months) 24 months (range, 3.1–252.6) 38 months (range, 10–242 months) 53 months (range, 1–302 months)
Re-irradiation dose 5 (1 – 8) x 5 Gy (3 – 16 Gy) 5 x 5 Gy 5 (2–5) x 6 3 x 10/13 Gy 5 x 6 Gy median dose of 40 Gy in 5 fractions (interquartile range, 30–44 Gy)
   5 x 6.4 Gy Gy (4–12Gy) 5 x 5/8 Gy   
   5 x 7.2 Gy     
   5 x 8.0 Gy median 30 Gy (21–35 Gy)    
   5 x 8.8 Gy     
Target size (median) TV 19.1 cm3 (range, 2.5 – 140.3 cm3) TV 44.8 mm3 (range, 4.2–216.6 mm3) Target volume 75 cm3 (range, 7–276 cm3) GTV 22.6 cm3 (range, 0.2 to 114.9 cm3) TV 63.4 cm3 (range 26.3–170.4 cm3) TV 19,6ml (range, 4.5 – 103.9 ml)
Median follow-up time 19 months (range 11–40 months) n/s 16 months 17.3 months 24 months 10 months (range, 0–55 months)
Local control 26% @ 2 years n/s 30% @ 2 years * 61% @ 1 year 82% @ 2 years 77% @ 6 months
     52.2% @ 2 years   59% @ 1 year
Overall survival 22% @ 2 years median 6 months (95% CI 5–8 months) 12 months 52.1% @ 1 year cancer specific survival 76% @ 6 months
    41% @ 2 years * 30.9% @ 2 years   
      64% @ 2 years 59% @ 1 year
Toxicity 1/22 grade 2, 3/25 grade 1 19/65 acute grade 1–3 toxicities 13/36 grade 3 acute toxicities 5/24 severe late side effects (grade ≥ 3) Acute/late grade 3 toxicity was 15/6%, with no grade 4–5 toxicity
  1/22 grade 3 mucositis 1/25 grade 2     
   No grade 3–5 toxicities   3/36 late toxicity: 1 bone necrosis, 2 soft tissue necrosis   
  No grade 4/5 toxicitiy      
    6/65 late grade 4 toxicities: arterial bleeding, soft    
    tissue necrosis, fistula formation    
    1 treatment related death    
  1. Abbreviations: BED10 = biologically effective dose (α/β of 10 for acute/tumor effects); n/s = not specified; @ = at time of; TV = tumor volume; GTV = gross tumor volume.
  2. * definitively treated patients.