Table 1 SBRT reirradiation for spinal metastases
From: Stereotactic body radiation therapy in the re-irradiation situation – a review
Clinical trial | No. patients/treatments | Dose 1st RT course (median) | Interval (median months) | Reirradiation TD/fraction number (median) | Accumulated dose to spinal cord EQD2 (median) | Planning | Set-up/imaging | Follow-up (months) | Myelopathy | Local/pain control |
|---|---|---|---|---|---|---|---|---|---|---|
Milker-Zabel et al. 2003 | 18/19 | 38Gy | 17.7 | 39.6Gy | n/s | ss-IMRT | Stereotactic | 12.3 | 0% | 94.7% |
Mahan et al. 2005 | 8/8 | 30Gy | n/s | 30Gy/15 | 48Gy | Tomotherapy | Daily MV-CT | 15.2 | 0% | 100% at time of fu |
Sahgal et al. 2009 | 25/37 | 36Gy | 11 | 24Gy/3 | n/s | Cyberknife | kV tracking | 7 | 0% | 70% |
Choi 2010 | 42/51 | 40Gy | 19 | 20Gy/2 | 76Gy | Cyberknife | kV tracking | 7 | n=1 G4 | 73% |
Sterzing et al. 2010 | 36/36 | 36.3Gy | 17.5 | 34.8Gy/11 | 46.5Gy | Tomotherapy | Daily MV-CT | 7.5 | 0% | 1-year 76% |
2-years 63% | ||||||||||
Damast et al. 2010 | 95/97 | 30Gy | n/s | 20-30Gy/5 | 54.3Gy | IMRT | Daily portal images or CBCT | 12.1 | 0% | 1-year 66% |
Garg et al. 2011 | 59/63 | 30Gy | n/s | 27-30Gy/3-5 | n/s | IMRT | Daily CT on rails or CBCT | 13 | n=2 G3 peripheral nerve injury | 76% |
Mahadevan et al. 2011 | 60/81 | 30Gy | 20 | 24-30Gy/3-5 | n/s | Cyberknife | kV tracking | 12 | n=3 persistent radicular pain | 93% |
n=1 lower-extremity weakness | ||||||||||
Chang et al. 2012 | 49/54 | 39.2Gy | 25 | 27Gy/3 | 83.4Gy | Cyberknife | kV tracking | 17.3 | 0% | 79% |