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Table 1 SBRT reirradiation for spinal metastases

From: Stereotactic body radiation therapy in the re-irradiation situation – a review

Clinical trial No. patients/treatments Dose 1st RT course (median) Interval (median months) Reirradiation TD/fraction number (median) Accumulated dose to spinal cord EQD2 (median) Planning Set-up/imaging Follow-up (months) Myelopathy Local/pain control
Milker-Zabel et al. 2003 18/19 38Gy 17.7 39.6Gy n/s ss-IMRT Stereotactic 12.3 0% 94.7%
Mahan et al. 2005 8/8 30Gy n/s 30Gy/15 48Gy Tomotherapy Daily MV-CT 15.2 0% 100% at time of fu
Sahgal et al. 2009 25/37 36Gy 11 24Gy/3 n/s Cyberknife kV tracking 7 0% 70%
Choi 2010 42/51 40Gy 19 20Gy/2 76Gy Cyberknife kV tracking 7 n=1 G4 73%
Sterzing et al. 2010 36/36 36.3Gy 17.5 34.8Gy/11 46.5Gy Tomotherapy Daily MV-CT 7.5 0% 1-year 76%
  2-years 63%
Damast et al. 2010 95/97 30Gy n/s 20-30Gy/5 54.3Gy IMRT Daily portal images or CBCT 12.1 0% 1-year 66%
Garg et al. 2011 59/63 30Gy n/s 27-30Gy/3-5 n/s IMRT Daily CT on rails or CBCT 13 n=2 G3 peripheral nerve injury 76%
Mahadevan et al. 2011 60/81 30Gy 20 24-30Gy/3-5 n/s Cyberknife kV tracking 12 n=3 persistent radicular pain 93%
  n=1 lower-extremity weakness  
Chang et al. 2012 49/54 39.2Gy 25 27Gy/3 83.4Gy Cyberknife kV tracking 17.3 0% 79%
  1. Abbreviations: RT = radiotherapy; TD = total dose; n/s = not specified; ss-IMRT = single shot intensity-modulated radiation therapy; MV-CT = megavolt computed tomography; kV = kilo Volt; CBCT = cone beam computed tomography; IMRT = intensity modulated radiation therapy; G = grade.