Skip to main content

Advertisement

Table 1 Radiobiological parameter values

From: Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma

Treatment LN18 T98G U87 U251
  α (Gy-1) β (Gy-2) SER50 (p) SER37 (p) α (Gy-1) β (Gy-2) SER50 (p) SER37 (p) α (Gy-1) β (Gy-2) SER50 (p) SER37 (p) α (Gy-1) β (Gy-2) SER50 (p) SER37 (p)
X-rays 0.08 ± 0.02 0.04 ± 0.01 - - 0.04 ± 0.02 0.05 ± 0.01 - - 0.15 ± 0.04 0.04 ± 0.01 - - 0.01 ± 0.02 0.06 ± 0.01 - -
X-rays + 5/10 μM TMZ 0.13 ± 0.02 0.04 ± 0.01 1.08 (0.32) 1.06 (0.36) 0.02 ± 0.01 0.05 ± 0.01 0.95 (0.52) 0.96 (0.50) 0.12 ± 0.05 0.05 ± 0.01 0.99 (0.93) 1.01(0.92) 0.04 ± 0.03 0.06 ± 0.01 1.08 (0.24) 1.06 (0.30)
X-rays + 5 μM ABT-888 0.18 ± 0.02 0.04 ± 0.01 1.28 (0.01) 1.23 (0.01) 0.12 ± 0.02 0.04 ± 0.01 1.16 (0.25) 1.12 (0.20) 0.21 ± 0.02 0.04 ± 0.01 1.13 (0.16) 1.12 (0.17) 0.12 ± 0.02 0.07 ± 0.01 1.37 (0.002) 1.31 (0.002)
X-rays + 5 μM ABT-888 + 5/10 μM TMZ 0.16 ± 0.01 0.05 ± 0.01 1.25 (0.02) 1.21 (0.01) 0.15 ± 0.01 0.04 ± 0.01 1.30 (0.03) 1.24 (0.01) 0.33 ± 0.02 0.02 ± 0.01 1.30 (0.03) 1.24 (0.04) 0.20 ± 0.01 0.05 ± 0.01 1.44 (0.003) 1.35 (0.001)
  1. Mean values of α, β, SER50 and SER37 (including p values) of MGMT-unmethylated LN18 and T98G cells, and of MGMT-methylated U87 and U251 cells, estimated by fitting the cell survival to the LQ model.