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Table 1 Radiobiological parameter values

From: Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma

Treatment

LN18

T98G

U87

U251

 

α (Gy-1)

β (Gy-2)

SER50 (p)

SER37 (p)

α (Gy-1)

β (Gy-2)

SER50 (p)

SER37 (p)

α (Gy-1)

β (Gy-2)

SER50 (p)

SER37 (p)

α (Gy-1)

β (Gy-2)

SER50 (p)

SER37 (p)

X-rays

0.08 ± 0.02

0.04 ± 0.01

-

-

0.04 ± 0.02

0.05 ± 0.01

-

-

0.15 ± 0.04

0.04 ± 0.01

-

-

0.01 ± 0.02

0.06 ± 0.01

-

-

X-rays + 5/10 μM TMZ

0.13 ± 0.02

0.04 ± 0.01

1.08 (0.32)

1.06 (0.36)

0.02 ± 0.01

0.05 ± 0.01

0.95 (0.52)

0.96 (0.50)

0.12 ± 0.05

0.05 ± 0.01

0.99 (0.93)

1.01(0.92)

0.04 ± 0.03

0.06 ± 0.01

1.08 (0.24)

1.06 (0.30)

X-rays + 5 μM ABT-888

0.18 ± 0.02

0.04 ± 0.01

1.28 (0.01)

1.23 (0.01)

0.12 ± 0.02

0.04 ± 0.01

1.16 (0.25)

1.12 (0.20)

0.21 ± 0.02

0.04 ± 0.01

1.13 (0.16)

1.12 (0.17)

0.12 ± 0.02

0.07 ± 0.01

1.37 (0.002)

1.31 (0.002)

X-rays + 5 μM ABT-888 + 5/10 μM TMZ

0.16 ± 0.01

0.05 ± 0.01

1.25 (0.02)

1.21 (0.01)

0.15 ± 0.01

0.04 ± 0.01

1.30 (0.03)

1.24 (0.01)

0.33 ± 0.02

0.02 ± 0.01

1.30 (0.03)

1.24 (0.04)

0.20 ± 0.01

0.05 ± 0.01

1.44 (0.003)

1.35 (0.001)

  1. Mean values of α, β, SER50 and SER37 (including p values) of MGMT-unmethylated LN18 and T98G cells, and of MGMT-methylated U87 and U251 cells, estimated by fitting the cell survival to the LQ model.