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Table 3 Summary of MRS data obtained from single-voxel (SV) acquisitions and from 2D spectroscopic imaging (2D-SI) in the three patients

From: Magnetic resonance spectroscopic study of radiogenic changes after radiosurgery of cerebral arteriovenous malformations with implications for the differential diagnosis of radionecrosis

No. Single-voxel MRS (SV) in AVM lesion   2D-SI   
          contra-lateral
  Cho/Cr NAA/Cr [Cho] [Cr] [NAA] Cho Cr NAA Cho/Cr NAA/Cr
  metabolite ratios (mmol/L) (mmol/L) (mmol/L) signal ratios lesion/contra-lateral metabolite ratios
1 a 2.08 0.39 1.59 2.86 0.80 0.84 0.32 0.09 1.23 2.15
1 b 2.67 0.46 1.41 1.98 0.65 0.81 0.41 0.22 1.02 1.97
2 1.38 1.05 1.68 5.02 3.78 0.64 0.62 0.34 1.27 2.27
3 1.69 1.23 2.00 4.49 4.01 0.46 0.28 0.26 0.98 1.74
Normal values (from [19])        
Mean 1.11 2.81 2.07 6.99 14.51      
SD 0.16 0.29 0.40 0.85 1.42      
  1. In the first column, 1a and 1b denote the initial and the second (4 months later) therapy follow-up MRI/MRS examination of patient #1, respectively. In the next columns, Cho/Cr and NAA/Cr represent metabolic ratios determined from the SV spectra at TE 140 ms, and the absolute concentrations of choline, creatine, and NAA as derived from the SV acquisitions in the lesion are listed. The 2D-SI results comprise the ratios of the signal intensity of the respective metabolite within the AVM lesion relative to that in the corresponding voxels in the unaffected contra-lateral hemisphere, and in the last two columns the metabolite ratios Cho/Cr and NAA/Cr measured in the contra-lateral voxels are shown. Below the patient results, normal values for relative and absolute metabolite levels in frontal/parietal white matter, taken from [19] are given for comparison.