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Table 3 Univariate and multivariate analysis of predictive factors for pCR (n = 138)

From: Carcinoembryonic antigen (CEA) level, CEA ratio, and treatment outcome of rectal cancer patients receiving pre-operative chemoradiation and surgery

 

Univariate analysis

Variable

Odds ratio

95% CI

p -value

Gender

   

 Male

0.357

0.146–0.872

0.024

 Female

1

  

Age

1.016

0.979–1.054

0.403

Clinical T stage

   

 cT2

1.244

0.375–4.129

0.721

 cT3-4

1

  

Clinical N stage

   

 cN0-1

0.527

0.167–1.661

0.274

 cN2

1

  

Clinical stage grouping

   

 Stage I-II

0.578

0.183–1.829

0.351

 Stage III-IV †

1

  

Distance from anal verge

0.949

0.794–1.136

0.571

RT-surgery interval

1.028

0.991–1.066

0.138

Pre-CRT CEA level

1.009

0.997–1.020

0.152

Post-CRT CEA level

0.676

0.478–0.955

0.026

CEA change groups

   

 Group L

4.371

0.545–35.069

0.165

 Group H-L

5.040

0.569–44.636

0.146

 Group H-H

1

  

CEA ratio

0.923

0.290–2.938

0.892

 

Multivariate analysis

Variable

Odds ratio

95% CI

p -value

Post-CRT CEA level

0.605

0.412–0.890

0.011

  1. Abbreviations: pCR, pathologic complete response; CRT, chemoradiotherapy; CEA, carcinoembryonic antigen; CI, confidence interval; RT, radiotherapy.
  2. † One patient was staged as clinical stage IV due to suspected lymph nodes at the root of inferior mesenteric artery.
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Radiation Oncology

ISSN: 1748-717X

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