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Table 2 Univariate and multivariate analysis of predictive factors for DFS (n = 138)

From: Carcinoembryonic antigen (CEA) level, CEA ratio, and treatment outcome of rectal cancer patients receiving pre-operative chemoradiation and surgery

 

Univariate analysis

Variable

No. of patients

5-year DFS (%)

p value

Gender

   

 Male

98

66.5

0.775

 Female

40

68.2

 

Age

   

 ≤60

57

61.1

0.461

 >60

81

72.0

 

Clinical T stage

   

 cT2

19

82.0

0.089

 cT3-4

119

64.5

 

Clinical N stage

   

 cN0

34

76.0

0.235

 cN1-2

104

64.0

 

Pathologic T stage

   

 ypT0, Tis, T1-2

70

81.5

<0.001

 ypT3-4

68

51.3

 

Pathologic N stage

   

 ypN0

100

80.1

<0.001

 ypN1-2

38

32.5

 

pCR

   

 Yes

25

94.4

0.001

 No

113

60.7

 

Distance from anal verge

   

 ≤6 cm

82

64.9

0.847

 >6 cm

56

69.9

 

Surgery type

   

 APR

24

57.6

0.346

 LAR

114

69.8

 

CEA change groups

   

 Group L

87

69.0

0.024

 Group H-L

32

74.5

 

 Group H-H

19

44.9

 
 

Multivariate analysis

Variable

Hazard ratio

95% CI

p value

Pathologic N stage

   

 ypN0

1

  

 ypN1-2

3.300

1.840–5.916

<0.001

pCR

   

 Yes

1

  

 No

8.502

1.143–63.228

0.037

  1. Abbreviations: DFS, disease-free survival; CI, Confidence interval; pCR, pathologic complete response; CRT, chemoradiotherapy; RT, Radiotherapy; CEA, carcinoembryonic antigen.
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Radiation Oncology

ISSN: 1748-717X

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