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Figure 6 | Radiation Oncology

Figure 6

From: Increased radiosensitivity and radiothermosensitivity of human pancreatic MIAPaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitorNVP-HSP990

Figure 6

Effect of treatments on mitotic catastrophe (A). Representativeimage showing aberrant mitotic figures and increased numbers ofmultinucleated and apoptotic cells observed in U251 cell culture treatedwith NVP-HSP990, hyperthermia and γ-IR. 72 hours or120 hours after γ-IR, DAPI was used to stain the DNA. Yellowarrowheads indicate multinucleated, white arrowheads apoptotic (withcondensed DNA) and red arrowheads cells with aberrant mitotic figures.Quantification was performed after 72 h (B) or120 hours (C) after IR. 200 cells were counted per sample.Mean value and SEM of 3 independent experiments are shown.

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