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Table 2 Effect of CRT on adiposity indexes and metabolic profile in 56 survivors of childhood ALL

From: Cranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemia

   Exposure to CRT Effect of CRT
Total No Yes
(n = 56) (n = 31) (n = 25)
Variable Mean (SD) Mean (SD) Mean (SD) Mean difference (Yes – No) SE 95%CI p
BMI (kg/m 2 ) 22.7 (4.3) 21.7 (3.4) 23.8 (4.9) 2.13 1.12 [-0.12; 4.38] 0.063
BMI (Z score) 0.07 (1.17) -0.09 (1.20) 0.27 (1.12) 0.35 0.31 [-0.28; 0.98] 0.266
FMI (kg/m 2 ) 6.7 (3.1) 5.8 (2.8) 7.7 (3.3) 2.14 0.73 [0.67; 3.61] 0.005
WC (cm) 81.1 (12.2) 78.9 (10.2) 83.8 (14.1) 4.80 3.25 [-1.71; 11.31] 0.145
HC (cm) 94.1 (8.0) 92.9 (7.6) 95.5 (8.4) 2.48 2.14 [-1.81; 6.78] 0.251
Waist-to-hip ratio 0.86 (0.08) 0.85 (0.07) 0.87 (0.10) 0.02 0.02 [-0.02; 0.06] 0.335
Waist-to-height ratio 0.50 (0.07) 0.48 (0.06) 0.52 (0.09) 0.04 0.02 [0.00; 0.08] 0.065
TAT (cm 3 ) 467.0 (279.4) 374.6 (212.0) 581.5 (313.1) 206.91 70.38 [65.81; 348.01] 0.005
VAT (cm 3 ) 109.6 (64.1) 88.8 (52.6) 135.3 (68.7) 46.42 16.21 [13.92; 78.91] 0.006
SAT (cm 3 ) 357.4 (231.2) 285.8 (177.6) 446.3 (261.2) 160.49 58.80 [42.60; 278.38] 0.009
VAT/SAT 0.40 (0.30) 0.41 (0.34) 0.37 (0.25) -0.07 0.07 [-0.21; 0.08] 0.351
Total cholesterol (mmol/L) 3.9 (0.9) 3.6 (0.8) 4.3 (1.0) 0.65 0.24 [0.16; 1.13] 0.010
LDL cholesterol (mmol/L) 2.2 (0.7) 2.0 (0.6) 2.6 (0.7) 0.57 0.18 [0.21; 0.93] 0.003
HDL cholesterol (mmol/L) 1.2 (0.3) 1.2 (0.3) 1.2 (0.3) 0.02 0.08 [-0.13; 0.18] 0.754
Triglycerides (mmol/L) 1.0 (0.5) 1.0 (0.5) 1.1 (0.5) 0.14 0.14 [-0.14; 0.42] 0.313
Glucose (mmol/L) 4.7 (0.4) 4.6 (0.3) 4.8 (0.4) 0.12 0.10 [-0.08; 0.31] 0.231
Insulin (pmol/L) 65.7 (30.8) 61.5 (27.5) 70.8 (34.2) 9.30 8.25 [-7.25; 25.84] 0.265
HOMA1-IR 2.01 (1.04) 1.85 (0.92) 2.20 (1.16) 0.34 0.28 [-0.21; 0.90] 0.221
  1. CRT Cranial radiotherapy, ALL Acute lymphocytic leukemia, SD Standard deviation, SE Standard error, CI Confidence interval, BMI Body mass index, FMI Fat mass index, WC Waist circumference, HC Hip circumference, TAT Total adipose tissue, VAT Visceral adipose tissue, SAT Subcutaneous adipose tissue, LDL Low-density lipoprotein, HDL High-density lipoprotein, HOMA1-IR Homeostatic model assessment - insulin resistance.