Phase I study of hypofractionated intensity modulated radiation therapy with concurrent and adjuvant temozolomide in patients with glioblastoma multiforme

Table 5 Univariate and multivariate analysis of prognostic factors for PFS

	Univariate			Multivariate
Variable	HR	95% CI	P	HR	95% CI	P
KPS
≥ 80 vs. 70	0.4	0.16-0.99	0.048	0.29	0.09-1.00	0.049
RPA class
Class III vs. Class IV and V	0.34	0.10-1.11	0.075			NS
Adjuvant TMZ
≥3 cycles vs. < 3 cycles	0.84	0.72-0.982	0.028	0.79	0.65-0.96	0.02
Extent of resection
GTR vs. biopsy or STR	0.54	0.15-1.91	0.339			NS
Time interval between the date of surgery and start of RT
≥ 6 weeks vs. < 6 weeks	1.08	0.45-2.59	0.867			NS

Abbreviations: PFS: progression free survival; HR: hazard ration; CI: confidence interval; KPS: Karnofsky performance status; RPA: recursive partitioning analysis; TMZ: Temozolomide; GTR: gross total resection; STR: subtotal resection; RT: radiation therapy.

ISSN: 1748-717X