Is adjuvant radiotherapy warranted in resected pT1-2 node-positive rectal cancer?

Peng, Junjie; Li, Xinxiang; Ding, Ying; Shi, Debing; Wu, Hongbin; Cai, Sanjun

doi:10.1186/1748-717X-8-290

Radiation Oncology

Table 1 Demographic characteristics and different outcomes of patients with pT1-2 node-positive rectal cancer

From: Is adjuvant radiotherapy warranted in resected pT1-2 node-positive rectal cancer?

Characteristics		No. (%) n = 219	5 y LR rate(%)	P value	5 y DM rate(%)	P value	5 y DFS rate(%)	P value	5 y OS rate(%)	P value
Gender
	Male	116 (53.0)	16.6	0.095	38.4	0.305	57.6	0.162	72.4	0.428
	Female	103 (47.0)	8.1	0.095	28.5	0.305	69.1	0.162	81.0	0.428
Age
	<60	130 (59.4)	13.6	0.618	26.7	0.754	70.4	0.589	81.9	0.378
	≥60	89 (40.6)	10.7	0.618	42.8	0.754	53.5	0.589	70.2	0.378
Tumor Location*
	Low	155 (70.8)	15.2	0.072	34.1	0.495	61.9	0.976	74.8	0.919
	High-Medium	64 (29.2)	6.1	0.072	31.5	0.495	66.8	0.976	80.6	0.919
CEA(ng/ul)
	<5	147 (67.1)	12.9	0.964	33.3	0.784	63.5	0.828	76.0	0.384
	≥5	72 (32.9)	12.0	0.964	34.7	0.784	61.8	0.828	74.6	0.384
Tumor Size
	<3.5	100 (45.7)	13.0	0.935	30.3	0.346	66.8	0.423	73.7	0.898
	≥3.5	119 (54.3)	12.1	0.935	35.6	0.346	60.8	0.423	77.8	0.898
Surgery**
	AR	114 (52.1)	4.8	0.002	29.9	0.423	69.0	0.621	81.3	0.782
	APR	105 (47.9)	19.9	0.002	34.2	0.423	59.6	0.621	73.3	0.782
Histopathology
	Adenocarcinoma	200 (91.3)	11.9	0.510	32.6	0.931	64.2	0.522	76.9	0.681
	Mucinous Cancer	19 (8.7)	17.1	0.510	33.7	0.931	59.9	0.522	75.1	0.681
Tumor Grade
	High	30 (13.7)	12.9	0.978	42.6	0.684	54.5	0.856	67.9	0.912
	Low-Medium	189 (86.3)	12.5	0.978	31.8	0.684	64.5	0.856	77.7	0.912
T Stage
	T1	61 (27.9)	6.9	0.202	43.1	0.145	57.8	0.746	81.1	0.832
	T2	158 (72.1)	14.3	0.202	29.9	0.145	64.9	0.746	76.1	0.832
N Stage
	N1	162 (74.0)	8.7	0.007	27.6	0.012	70.4	0.001	81.8	0.002
	N2	57 (26.0)	23.0	0.007	49.9	0.012	43.9	0.001	62.5	0.002
Sampled Lymph Nodes
	<12	106 (48.4)	9.8	0.291	35.2	0.509	61.8	0.927	77.5	0.864
	≥12	113 (51.6)	15.5	0.291	31.0	0.509	64.9	0.927	76.3	0.864
PNI/LVI
	No	148 (67.6)	9.7	0.144	28.9	0.028	68.1	0.043	78.3	0.705
	Yes	71 (32.4)	18.7	0.144	41.6	0.028	53.7	0.043	73.2	0.705
Adjuvant Treatment
	No	49 (22.4)	23.5	0.131	49.5	0.384	48.2	0.930	82.1	0.685
	Adjuvant CT	98 (44.7)	11.2		25.8		69.1		80.5
	Adjuvant CRT	72 (32.9)	7.5		42.4		56.5		61.3

*Tumor location: Low, within 6 cm from anal verge; High-Medium, from 6 to 15 cm from anal verge.
**Abbreviations: AR Anterior Resection, APR Abdominoperineal Resection, CT Chemotherapy, CRT Chemoradiotherapy, PNI perineural invasion, LVI lymphovascular invasion.

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ISSN: 1748-717X

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