Figure 4
From: Sonoporation as an enhancing method for boron neutron capture therapy for squamous cell carcinomas
Histological examination of tumors. Nude mouse tumors in the untreated control group (A) and BPA-mediated BNCT in combination with sonoporation group (B, C and D) were subjected to histological examinations. Twenty four hours after treatment, the vacuolation of tumor cells, fragmentation of nuclei, enlarged and multinucleated cells were observed (B). Although vacuolation appeared in the dermis, cell layers in the epidermis (arrow head) were preserved without degradation (C and D). Arrows showed the margin of the tumors produced by subcutaneous inoculation of SAS cells (C).