Table 2 Cumulative incidence of a rectosigmoid mucosal change (RMC) score ≥ 3 and late rectal complication (LRC) grade ≥ 2 in relation to various dose-volumetric parameters receiving three different dose subgroups

D_RP (Gy₃)

< 65

8/25 (32.0)

0.260

7/25 (28.0)

0.070

65–74.9

7/27 (25.9)

4/27 (14.8)

≥ 75

12/25 (48.0)

11/25(44.0)

D_0.1cc (Gy₃)

< 80

4/19 (21.1)

0.046

2/19 (10.5)

0.066

80–94.9

9/32 (28.1)

9/32 (28.1)

≥ 95

14/26 (53.9)

11/26 (42.3)

D_1cc (Gy₃)

< 75

8/36 (22.2)

0.021

6/36 (16.7)

0.021

75–89.9

10/27 (37.0)

8/27 (29.6)

≥ 90

9/14 (64.3)

8/14 (57.1)

D_2cc (Gy₃)

< 70

5/30 (16.7)

0.010

4/30 (13.3)

0.041

70–84.9

10/26 (38.5)

9/26 (34.6)

≥ 85

12/21 (57.1)

9/21 (42.9)

D_5cc (Gy₃)

< 65

4/31(12.9)

0.002

3/31 (9.7)

0.002

65–74.9

13/30 (43.3)

10/30 (33.3)

≥ 75

10/16 (62.5)

9/16 (56.3)

D_10cc (Gy₃)

< 60

6/32 (18.8)

0.017

5/32 (15.6)

0.082

60–64.9

10/26 (38.5)

9/26 (34.6)

≥ 65

11/19 (57.9)

8/19 (42.1)

D_15cc (Gy₃)

< 55

4/28 (14.3)

0.006

4/28 (14.3)

0.036

55–59.9

6/17 (35.3)

4/17 (23.5)

≥ 60

17/32 (53.1)

14/32 (43.8)

D_20cc (Gy₃)

< 55

5/30 (16.7)

0.011

5/30 (16.7)

0.092

55–59.9

8/22 (36.4)

6/22 (27.3)

≥ 60

14/25 (56.0)

11/25 (44.0)