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Table 1 Associations of clinical and dose-volumetric parameters parameters with the rectosigmoid mucosal change score (RMC) ≥ 3 and late rectal complication (LRC) grade ≥ 2

From: A prospective observational study with dose volume parameters predicting rectosigmoidoscopic findings and late rectosigmoid bleeding in patients with uterine cervical cancer treated by definitive radiotherapy

  

Total

RMC

 

LRC

 
  

Patients, n (%)

Score < 3, n (%)

≥ Score 3, n (%)

p-value

Grade < 2, n (%)

Grade ≥ 3, n (%)

p-value

Age (years)

≤ 60

50 (64.9)

35 (70)

15 (30)

0.222*

38 (76)

12 (24)

0.292*

 

> 60

27 (35.1)

15 (55.6)

12 (44.4)

 

17 (63)

10 (37)

 

Histology

Squamous cell carcinoma

70 (90.9)

44 (62.9)

26 (37.1)

0.411*

49 (70)

21 (30)

0.666*

 

Adenocarcinoma

7 (9.1)

6 (85.7)

1 (14.3)

 

6 (85.7)

1 (14.3)

 

Tumor size (cm)

≤ 4

41 (53.2)

29 (70.7)

12 (29.3)

0.339*

32 (78)

9 (22)

0.210*

 

> 4

36 (46.8)

21 (58.3)

15 (41.7)

 

23 (63.9)

13 (36.1)

 

Stage

IB-IIA

32 (41.6)

27 (84.4)

5 (15.6)

0.003*

29 (90.6)

3 (9.4)

0.002*

 

IIB-IIIB

45 (58.4)

23 (51.1)

22 (48.9)

 

26 (57.8)

19 (42.2)

 

Concurrent chemotherapy

Yes

66 (85.7)

43 (65.2)

23 (34.8)

1.000*

48 (72.7)

18 (27.3)

0.719*

 

No

11 (14.3)

7 (63.6)

4 (36.4)

 

7 (63.6)

4 (36.4)

 

Diabetes Mellitus

Yes

6 (7.8)

5 (83.3)

1 (16.7)

0.417*

5 (83.3)

1 (16.7)

0.668*

 

No

71 (92.2)

45 (16.7)

26 (44.4)

 

50 (70.4)

21 (29.6)

 

Hypertension

Yes

20 (26)

10 (50)

10 (50)

0.172*

12 (60)

8 (40)

0.251*

 

No

57 (74)

40 (70.2)

17 (29.8)

 

43 (75.4)

14 (24.5)

 

Smoking

Yes

12 (15.6)

10 (83.3)

2 (16.7)

0.491*

9 (75)

3 (25)

0.524*

 

No

65 (84.4)

45 (69.2)

20 (30.8)

 

41 (63.1)

24 (36.9)

 

DRP (Gy3)

(μ ± σ)

 

69.1 ± 12.3

75.4 ± 18.3

0.124†

69.2 ± 11.9

76.7 ± 20.0

0.120†

D0.1cc (Gy3)

(μ ± σ)

 

87.2 ± 15.6

101.7 ± 26.7

0.014†

87.9 ± 15.9

103.1 ± 28.4

0.026†

D1cc (Gy3)

(μ ± σ)

 

75.1 ± 10.9

85.2 ± 14.4

0.001†

75.8 ± 11.1

85.6 ± 15.2

0.002†

D2cc (Gy3)

(μ ± σ)

 

70.8 ± 9.8

79.6 ± 11.5

0.001†

71.5 ± 9.9

79.9 ± 12.0

0.002†

D5cc (Gy3)

(μ ± σ)

 

64.6 ± 8.2

72.0 ± 8.4

< 0.001†

65.2 ± 8.3

72.2 ± 8.8

0.002†

D10cc (Gy3)

(μ ± σ)

 

59.5 ± 6.4

63.4 ± 6.0

0.011†

60.1 ± 6.7

62.7 ± 5.8

0.107†

D15cc (Gy3)

(μ ± σ)

 

56.3 ± 5.8

60.2 ± 5.0

0.004†

56.8 ± 5.8

59.9 ± 5.3

0.034†

D20cc (Gy3)

(μ ± σ)

 

55.4 ± 5.8

59.1 ± 4.8

0.006†

55.9 ± 5.9

58.8 ± 4.9

0.040†

  1. Abbreviations: DRP = doses to the reference points for the rectum; D0.1cc, D1cc, D2cc, D5cc, D10cc, D15cc, and D20cc = minimal doses received by the highest irradiated 0.1, 1, 2, 5, 10, 15, and 20 cc volumes of the rectosigmoid colon, respectively.; μ = mean; σ = standard deviation.
  2. *Fisher’s exact test.
  3. † Student’s t-test.
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Radiation Oncology

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