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Table 3 Relationship between age and radiation pneumonitis in 3D-CRT for BC in world literature

From: Meta-analysis of incidence of early lung toxicity in 3-dimensional conformal irradiation of breast carcinomas

Author, Year* Country n RP endpoint Prognostic groups Test type (results) p value Comments
Lind et al. 1994 1998 [20] Duke’s 613 Clinical RP, Grade > 2 Median age Mann–Whitney test 0.64 RP > Grade 2 only (retrospective)
(RP- vs RP+) (54.9 yrs vs 55.2 yrs)
Lind et al. 1994 1998 [17] Sweden 180 Clinical RP CTC-NCIC Mean age Students t-test <0.001 Loco-regional RT after mastectomy
(RP- vs RP+) (55.4 yrs vs 62.6 yrs)
Kahan et al. 2001 – 2004 [31] Hungary 119 Radiological RP – CTC 2.0 Mean age Student’s t-test 0.012 -
(RP- vs RP+) (56.2 yrs vs 61.5 yrs)
Jaen et al. 2002 [44] Spain 39 Perfused lung volume (%) ≤55 yrs, >55 yrs Box plot: ≤55 yrs vs >55 yrs NS Reduced perfusion in older age group
Kubo et al. 2005 – 2007 [24] Japan 413 Radiological RP – CTC/AE 3.0 ≤50 yrs,>50 yrs Cox regression model 0.20 Only tangential whole breast irradiation
(RR = 0.76, 95% CI 0.49 – 1.2)
  1. RP radiation pneumonitis, n number of patients, CI confidence interval, CTC/CTC-NCIC common toxicity criteria, RT radiotherapy, *year of data collection, NS statistically not significant.