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Table 3 Relationship between age and radiation pneumonitis in 3D-CRT for BC in world literature

From: Meta-analysis of incidence of early lung toxicity in 3-dimensional conformal irradiation of breast carcinomas

Author, Year*

Country

n

RP endpoint

Prognostic groups

Test type (results)

p value

Comments

Lind et al. 1994 1998 [20]

Duke’s

613

Clinical RP, Grade > 2

Median age

Mann–Whitney test

0.64

RP > Grade 2 only (retrospective)

(RP- vs RP+)

(54.9 yrs vs 55.2 yrs)

Lind et al. 1994 1998 [17]

Sweden

180

Clinical RP CTC-NCIC

Mean age

Students t-test

<0.001

Loco-regional RT after mastectomy

(RP- vs RP+)

(55.4 yrs vs 62.6 yrs)

Kahan et al. 2001 – 2004 [31]

Hungary

119

Radiological RP – CTC 2.0

Mean age

Student’s t-test

0.012

-

(RP- vs RP+)

(56.2 yrs vs 61.5 yrs)

Jaen et al. 2002 [44]

Spain

39

Perfused lung volume (%)

≤55 yrs, >55 yrs

Box plot: ≤55 yrs vs >55 yrs

NS

Reduced perfusion in older age group

Kubo et al. 2005 – 2007 [24]

Japan

413

Radiological RP – CTC/AE 3.0

≤50 yrs,>50 yrs

Cox regression model

0.20

Only tangential whole breast irradiation

(RR = 0.76, 95% CI 0.49 – 1.2)

  1. RP radiation pneumonitis, n number of patients, CI confidence interval, CTC/CTC-NCIC common toxicity criteria, RT radiotherapy, *year of data collection, NS statistically not significant.