Meta-analysis of incidence of early lung toxicity in 3-dimensional conformal irradiation of breast carcinomas

Radiation Oncology

Table 3 Relationship between age and radiation pneumonitis in 3D-CRT for BC in world literature

Author, Year^*	Country	n	RP endpoint	Prognostic groups	Test type (results)	p value	Comments
Lind et al. 1994– 1998 [20]	Duke’s	613	Clinical RP, Grade > 2	Median age	Mann–Whitney test	0.64	RP > Grade 2 only (retrospective)
Lind et al. 1994– 1998 [20]	Duke’s	613	Clinical RP, Grade > 2	(RP- vs RP+)	(54.9 yrs vs 55.2 yrs)	0.64	RP > Grade 2 only (retrospective)
Lind et al. 1994– 1998 [17]	Sweden	180	Clinical RP CTC-NCIC	Mean age	Students t-test	<0.001	Loco-regional RT after mastectomy
Lind et al. 1994– 1998 [17]	Sweden	180	Clinical RP CTC-NCIC	(RP- vs RP+)	(55.4 yrs vs 62.6 yrs)	<0.001	Loco-regional RT after mastectomy
Kahan et al. 2001 – 2004 [31]	Hungary	119	Radiological RP – CTC 2.0	Mean age	Student’s t-test	0.012	-
Kahan et al. 2001 – 2004 [31]	Hungary	119	Radiological RP – CTC 2.0	(RP- vs RP+)	(56.2 yrs vs 61.5 yrs)	0.012	-
Jaen et al. 2002 [44]	Spain	39	Perfused lung volume (%)	≤55 yrs, >55 yrs	Box plot: ≤55 yrs vs >55 yrs	NS	Reduced perfusion in older age group
Kubo et al. 2005 – 2007 [24]	Japan	413	Radiological RP – CTC/AE 3.0	≤50 yrs,>50 yrs	Cox regression model	0.20	Only tangential whole breast irradiation
Kubo et al. 2005 – 2007 [24]	Japan	413	Radiological RP – CTC/AE 3.0	≤50 yrs,>50 yrs	(RR = 0.76, 95% CI 0.49 – 1.2)	0.20	Only tangential whole breast irradiation

RP radiation pneumonitis, n number of patients, CI confidence interval, CTC/CTC-NCIC common toxicity criteria, RT radiotherapy, ^*year of data collection, NS statistically not significant.

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