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Table 6 Summary of the average DVH parameters in total dose (Gy) of the CV treatment technique, compared to other published values

From: Equivalence of Gyn GEC-ESTRO guidelines for image guided cervical brachytherapy with EUD-based dose prescription

DVH parameter CV Georg et al.[9] Georg et al.[10] Levitchi et al.[33] Jürgenliemk-Schulz et al.[38] Jürgenliemk-Schulz et al.[39] Nesvacil et al.[40] Lindegaard et al.[41]
Method HDR HDR HDR PDR PDR HDR/PDR HDR PDR
Rectum         
D0.1 cc 79 ± 1 88 ± 10* 83 - 132 a 83 b     
   81 ± 13** 86 ± 27** 65 ± 15**     74 ± 9**
D1cc 72 ± 2 76 ± 7* 71 - 87 a      
   70 ± 9** 69 ± 14**      69 ± 6**
D2cc 70 ± 2 72 ± 6* 67 - 78 a 68 b     
   66 ± 8** 65 ± 12** 57 ± 8** 66 ± 6** 54 ± 2** c 57 ± 6** 67 ± 6**
       69 ± 2** d   
Bladder         
D0.1 cc 100 ± 3   61 - 178 a 109 b     
    162 ± 75** 78 ± 22**     86 ± 12**
D1cc 86 ± 3   71 - 116 a      
    108 ± 31**      77 ± 8**
D2cc 81 ± 3   70 – 101 a 72 b 81 ± 6** 53 ± 2** c 76 ± 9**  
    95 ± 22** 64 ± 11**   101 ± 11** d   73 ± 6**
  1. Abbreviations: SD standard deviation, HDR high dose rate, PDR pulsed dose rate.
  2. *Clinical symptoms (LENT/SOMA) score 1–4 and Rectoscopic changes (VRS) score 3–5.
  3. **Population average; no interstitial needles.
  4. a5% - 10% probability of G2-G4 side effects (dose range not shown).
  5. bApproximately 10% probability of G2-G4 toxicity (dose range not shown).
  6. cSmall volume tumor.
  7. dLarge volume tumor.