2-Step adaptation for the QUASIMODO case (left) and for the real clinical case of prostate cancer treatment (right). Thin dashed line – native CT1 plan applied to the CT2 geometry (relocated plan for the clinical case), thin solid line – native plan for the CT2 geometry (“golden standard”). The numbers denote adaptation steps. For the QUASIMODO case two adaptation steps are shown: 1. Generation of the 2-Step segments for the CT2 geometry with MUs transferred from the CT1 plan; 2. Adaptation of S2 widths according to (1). For the real clinical case additional step is performed: 3. Imitation of DMPO shifts for CT2 segments.