Boost ratio as a function of dose prescription. Dose escalation sub-volumes for 64Cu-ATSM, FDG40 and FDG50 are shown on the left (A + C). Intersection and union volumes of the tracers are depicted on the right (B + D). Cu-ATSM refers to dose escalation to the Cu3 sub-volume. Intersection and union boosts also include the two FDG sub-volumes and Cu3. The solid lines represent mean values based on all 5 dogs, and the range (80%) is illustrated in shade colors.