Comparison of two preoperative chemoradiotherapy regimens for locally advanced rectal cancer: capecitabine alone versus capecitabine plus irinotecan

Table 2 Radiologic and pathologic evaluations of short-term tumor response

	Short-term tumor response	Capecitabine alone	Capecitabine/Irinotecan	p- value
Radiologic findings	Patients number	137	79
	Tumor volume reduction rate† (%)			0.731*
	Mean	65.6 ± 24.3	66.8 ± 22.5
	Median	71.7	72.0
	Range	0–100	2.3–100
	Clinical response (tumor volume reduction rate ≥ 65%)	82 (60)	52 (66)	0.384‡
Pathologic findings	Patients number	131	70
	Post-CRT stage			0.538‡
	0-I	60 (44.1)	35 (48.6)
	II-IV	76 (55.9)	37 (51.4)
	Tumor regression grade			0.247‡
	1 or 2	96 (71.3)	45 (62.5)
	3 or 4	40 (28.6)	27 (37.5)

CRT, chemoradiotherapy.
*Two-tailed t-test.
†Tumor volume reduction rate = (pre-CRT tumor volume – post-CRT tumor volume) × 100/pre-CRT tumor volume.
‡Two-tailed Fisher’s exact test.

ISSN: 1748-717X