Pre- and post- treatment testosterone levels and EPIC hormonal scores. (a) Box- and- Whisker plot of total testosterone levels. The p values were from χ2-analysis with baseline testosterone levels. (b) Average EPIC hormonal scores. Thresholds for clinically significant changes in scores (½ standard deviation above and below the baseline) are marked with dashed lines. EPIC scores range from 0–100 with higher values representing a more favorable health-related QOL.