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Table 2 Prognostic factors: univariate analysis

From: High-dose stereotactic body radiotherapy correlates increased local control and overall survival in patients with inoperable hepatocellular carcinoma

Characteristics

     Local control

Overall survival

 

2-year (%)

*P-value

2-year (%)

*P-value

Age (years)

≤ 60

79.5

59.6

> 60

92.8

0.019

66.3

NS

Gender

Male

83.3

 

57.8

 

Female

95.7

NS

76.8

NS

Diagnosis history at SBRT

Initially diagnosed

96.2

67.9

Recurrence

82.3

NS

60.3

NS

Child-Turcotte-Pugh score

A5, 6

85.3

60.1

B7

100.0

NS

87.5

NS

Portal vein tumor thrombosis

Yes

88.9

62.9

 

No

86.4

NS

62.5

NS

Alpha-fetoprotein (IU/ml)

≤ 200

88.4

66.3

 

> 200

81.5

NS

53.8

NS

AJCC stage

T1

93.7

71.3

 

T2, 3

73.2

0.031

53.8

NS

BCLC stage

A

93.7

74.7

 

B, C

78.8

0.018

51.0

0.011

Okuda stage

I

89.1

65.4

II

77.9

NS

55.0

NS

CLIP score

0

85.1

66.6

1, 2

88.6

NS

59.4

NS

Longest diameter (cm)

≤ 5.0

90.2

69.4

> 5.0

63.3

0.015

33.3

0.012

No. of previous TACE sessions

≤ 2

95.7

 

69.6

 

> 2

77.2

0.022

54.9

0.023

SBRT dose (Gy)

< 45

64.3

30.0

45–54

78.3

0.009

64.3

<0.001

 

> 54

100.0

71.3

  1. Abbreviations: SBRT stereotactic body radiotherapy, TACE transarterial chemoembolization, AJCC American Joint Committee on Cancer, BCLC Barcelona Clinic Liver Cancer, CLIP Cancer of the Liver Italian Program; NS not significant (p > 0.05).
  2. *P-value was calculated by log-rank test.