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Table 5 Comparison of toxicities of studies of SBRT for primary and metastatic liver tumors

From: Radiation-induced liver disease after stereotactic body radiotherapy for small hepatocellular carcinoma: clinical and dose-volumetric parameters

Study

Diagnosis

n

Dose prescription

Toxicity

Mendez Romero[11]

HCC, Mets

25 (8, 17)

10–12.5 Gy × 3 or 5 Gy × 5 (CP B)

4 RILD ≥ grade 3, one grade 5 (HCC patient with CP B)

Tse[13]

HCC, IHC

41 (31, 10)

4–9 Gy × 6

10 (8 HCC, 2 IHC) grade 3 liver enzyme, 3 (2 HCC, 1 IHC) grade 3 hyperbilirubinemia, no grade 4–5

Rusthoven[12]

HCC, Mets

47 (2, 45)

12–20 Gy × 3

1 grade 3 soft-tissue toxicity

Lee[14]

Mets

68

4.6–10 Gy × 6

2 grade 3 liver enzyme changes (d/t DP), but no RILD

Cardenes[9]

HCC

17

12 Gy × 3 → 16 Gy × 3 (CP A) or 8 Gy × 5 (CP B)

2 grade 3 liver toxicity in patients with CP B at 42 Gy/3fx

Son[18]

HCC

36

10–13 Gy × 3

12 grade 2 or higher hepatic toxicity, 4 progression of CP

Present study

HCC

92

10–20 Gy × 3–4

11 grade 2, 6 grade 3 or higher RILD

  1. Abbreviations: HCC hepatocellular carcinoma, Mets metastasis, CP Child-Pugh class, RILD radiation-induced liver disease, IHC intrahepatic cholangiocarcinoma, DP disease progression.