Table 3 Univariate analyses of clinical and dose-volumetric parameters associated with the risk of radiation-induced liver disease
Variables | < Grade 2 (%) | ≥ Grade 2 (%) | p-value |
|---|---|---|---|
Age (years) | 61.7 ± 8.7 | 59.3 ± 11.1 | 0.324 |
Gender | 0.323 | ||
Male | 61 (83.6) | 12 (16.4) | |
Female | 14 (73.7) | 5 (26.3) | |
ECOG performance score | 0.402 | ||
0-1 | 72 (80.9) | 17 (19.1) | |
2 | 3 (100.0) | 0 (0.0) | |
Child-Pugh class | 0.008 | ||
A | 59 (88.1) | 8 (11.9) | |
B | 16 (64.0) | 9 (36.0) | |
Viral etiology | 0.278 | ||
HBs-Ag (+) | 58 (84.1) | 11 (15.9) | |
HBs-Ag (-) | 17 (73.9) | 6 (26.1) | |
SBRT dose (Gy) | 46.5 ± 9.2 | 43.4 ± 8.8 | 0.200 |
Fraction size (Gy) | 14.0 ± 2.1 | 13.2 ± 1.9 | 0.124 |
Normal liver volume (cm3) | 1199.3 ± 251.0 | 1036.5 ± 300.2 | 0.022 |
GTV (cm3) | 15.9 ± 20.5 | 15.7 ± 12.8 | 0.965 |
PTV (cm3) | 58.5 ± 53.5 | 54.4 ± 31.0 | 0.761 |
Mean liver dose (Gy) | 8.6 ± 3.5 | 9.2 ± 4.5 | 0.569 |
D33%* (Gy) | 8.2 ± 4.7 | 9.3 ± 6.8 | 0.435 |
D50%† (Gy) | 4.5 ± 3.4 | 5.2 ± 4.6 | 0.494 |
rV60Gy | 1191.7 ± 249.8 | 1030.5 ± 300.9 | 0.023 |
rV55Gy | 1188.8 ± 249.8 | 1028.8 ± 301.2 | 0.024 |
rV50Gy | 1183.5 ± 249.0 | 1026.9 ± 300.9 | 0.027 |
rV45Gy | 1167.0 ± 244.6 | 1015.6 ± 294.1 | 0.029 |
rV40Gy | 1153.0 ± 244.8 | 999.7 ± 303.5 | 0.028 |
rV35Gy | 1133.9 ± 243.8 | 977.1 ± 307.2 | 0.025 |
rV30Gy | 1114.0 ± 243.1 | 959.4 ± 308.0 | 0.027 |
rV25Gy | 1086.7 ± 241.3 | 936.1 ± 308.1 | 0.030 |
rV20Gy | 1045.5 ± 239.0 | 900.0 ± 309.3 | 0.035 |
rV15Gy | 976.5 ± 237.7 | 835.8 ± 308.0 | 0.040 |
rV10Gy | 856.6 ± 249.9 | 728.9 ± 310.3 | 0.073 |
rV5Gy | 655.5 ± 262.8 | 569.4 ± 295.5 | 0.237 |