Treatment schedule. One treatment course comprises of proton beam radiotherapy (PBT) and 3 echo guided injections of CalTUMP every week. Delayed hypersensitivity test (DTH) using CalTUMP was performed 5–7 days after PBT. The first intratumoral injection of CalTUMP was performed 48 hours after DTH. The follow-up period was more than 1 year.