Table 2 Clinical variables, summary of dosimetric statistics and correlation coefficient (Rs) with radiation-induced late gastro-intestinal toxicity incidence
Univariate analysis | ||||
|---|---|---|---|---|
Characteristic | Rs | p-value | ||
Categorical | N | % | ||
Age (y) | ||||
≤70 | 19 | 33.3 | ||
>70 | 38 | 66.7 | 0.105 | .436 |
Tumor size | ||||
<T3 | 48 | 84.2 | ||
≥T3 | 9 | 15.8 | -0.044 | .752 |
PSA | ||||
≤15 | 35 | 61.4 | ||
>15 | 22 | 38.6 | 0.051 | .707 |
Gleason score | ||||
≤6 | 34 | 59.7 | ||
>6 | 23 | 40.3 | 0.143 | .315 |
Hormonal therapy | ||||
Yes | 53 | 7.0 | ||
No | 4 | 93.0 | -0.097 | .472 |
Previous abdominal surgery | ||||
Yes | 26 | 45.6 | ||
No | 31 | 54.4 | 0.025 | .854 |
Diabetes | ||||
Yes | 14 | 24.6 | ||
No | 43 | 75.4 | -0.058 | .670 |
Smokers | ||||
Yes | 31 | 54.4 | ||
No | 26 | 45.6 | 0.199 | .137 |
Antihypertensive/anticoagulants | ||||
Yes | 37 | 64.9 | ||
No | 20 | 35.1 | -0.338 | .010 |
Acute GI toxicity | ||||
Yes | 21 | 36.8 | ||
No | 36 | 63.2 | 0.309 | .020 |
Radiation treatment | ||||
CRT | 26 | 45.6 | ||
ART | 31 | 54.4 | -0.174 | .195 |
Continuous | Median (range) | |||
Dmax (Gy) | 76.2 (47.2-79.7) | -0.009 | .947 | |
Dmean (Gy) | 43.2 (14.9-74.9) | 0.242 | .035 | |
V30 (%) | 67.1 (16.8-100) | 0.203 | .131 | |
V40 (%) | 49.4 (12.3-100) | 0.244 | .067 | |
V50 (%) | 39.8 (8.2-99.1) | 0.274 | .039 | |
V60 (%) | 30.1 (2.6-98.0) | 0.282 | .034 | |
V65 (%) | 27.0 (0.4-98.2) | 0.284 | .032 | |
V70 (%) | 26.8 (0.0-97.0) | 0.255 | .056 | |
V75 (%) | 7.6 (0.0-81.7) | 0.068 | .615 | |