Table 4 Diffusion tensor imaging bortezomib interaction effect. Changes in radial diffusivity (RD) values by treatment group and white matter structures
From: Concurrent whole brain radiotherapy and bortezomib for brain metastasis
Group | Structures | Pre-RT to End-RT* | Pre-RT to 1 month post-RT# | ||
|---|---|---|---|---|---|
Change in RD | 95% CI | Change in RD | 95% CI | ||
No bortezomib | Other white matter | + 10.4% | 6.3 – 14.5% | + 5.8% | 1.1 – 10.5% |
Hippocampus-associated | + 13.2% | 7.5 – 18.8% | + 4.8% | −1.4 – 11.1% | |
With bortezomib | Other white matter | + 7.7% | 4.6 – 10.8% | + 8.1% | 4.8 – 11.5% |
Hippocampus-associated | + 17.2% | 13.0 – 21.5% | + 16.8%¶ | 12.4 – 21.2% | |