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Table 3 Comparison of the difference of manometric data between before and after nCRT according to each tumor characteristics

From: Short–term effects of neoadjuvant chemoradiation therapy on anorectal function in rectal cancer patients: a pilot study

 

Tumor location

Gross morphology

CIR

T stage

Tumor volume

 

>5 cm (n = 18)

≤5 cm (n = 12)

P-value

No change (n = 8)

Change (n = 22)

P-value

No reduced (n = 20)

Reduced (n = 10)

P-value

No reduced (n = 22)

Reduced (n = 8)

P-value

No reduced (n = 26)

Reduced (n = 4)

P-value

MRP (mmHg)

8.2 ± 26.9

20.7 ± 39.2

0.304

12.1 ± 24.5

13.6 ± 35.3

0.914

9.1 ± 25.4

21.5 ± 43.6

0.331

16.2 ± 32.6

4.9 ± 32.3

0.404

12.4 ± 33.8

18.6 ± 23.5

0.726

R asymmetry (%)

−3.8 ± 5.9

1.5 ± 23.7

0.371

−3.5 ± 5.0

−1.1 ± 17.9

0.700

−3.7 ± 5.7

2.5 ± 26.0

0.311

−10.1 ± 15.9

−3.4 ± 15.5

0.731

−2.2 ± 16.6

1.5 ± 3.1

0.670

MSP (mmHg)

39.5 ± 73.4

99.6 ± 261.9

0.362

21.9 ± 73.4

78.6 ± 197.1

0.438

35.2 ± 71.8

120.1 ± 284.1

0.212

74.6 ± 196.5

33.1 ±85.8

0.571

63.2 ± 184.2

65.5 ± 89.9

0.981

S asymmetry (%)

−0.7 ± 4.3

3.6 ±18.5

0.348

0.3 ± 3.8

1.3 ± 13.9

0.843

−1.2 ± 4.5

5.4 ± 19.8

0.162

1.2 ± 13.9

0.4 ±3.6

0.869

0.8 ± 12.9

2.0 ±1.2

0.860

HPZ length at rest (cm)

−0.1 ± 0.6

0.08 ±0.7

0.345

0.2 ± 0.6

−0.1 ± 0.6

0.140

−0.08 ± 0.6

0.02 ± 0.7

0.677

0.1 ± 0.5

−0.4 ±0.6

0.030

0.008 ±0.5

−0.4 ±0.8

0.215

HPZ length at squeezing (cm)

−0.02 ± 0.8

−0.2 ± 0.8

0.612

0.01 ± 1.0

−0.1 ± 0.7

0.696

−0.1 ± 0.9

−0.02 ± 0.4

0.762

−0.1 ± 0.8

0.06 ± 0.7

0.551

−0.06 ± 0.6

−0.3 ±0.3

0.658

RAIR (ml)

−2.2 ± 18.1

−5.0 ± 15.1

0.663

−7.5 ± 18.3

−1.8 ± 16.2

0.419

−4.0 ± 17.9

−2.0 ± 14.7

0.763

−7.3 ± 15.8

7.5 ± 14.8

0.029

−4.6 ± 17.3

5.0 ±10.0

0.291

Rectal sensory threshold (ml)

               

First

8.3 ± 38.8

1.7 ±21.2

0.593

16.25 ± 56.6

1.8 ± 18.7

0.292

4.0 ± 10.5

9.0 ± 56.5

0.700

10.0 ± 32.9

−6.2 ± 30.7

0.235

7.3 ±31.3

−5.0 ±44.3

0.493

Desire to defecate

9.4 ± 51.5

7.5 ± 51.9

0.920

31.3 ± 64.2

0.5 ± 43.8

0.145

19.5 ± 32.4

−13.0 ± 72.9

0.099

21.8 ± 41.7

−27.5 ± 58.5

0.016

15.4 ±45.3

−35.0 ± 70.0

0.063

Maximal

28.9 ± 55.2

25.8 ±49.4

0.878

41.3 ± 57.2

22.7 ± 50.6

0.399

36.5 ± 50.1

10.0 ± 54.2

0.194

30.9 ±58.1

18.8 ± 31.8

0.581

29.6 ± 54.9

15.0 ±30.0

0.610

Rectal compliance (ml/mmHg)

0.2 ± 0.7

−0.07 ± 0.5

0.283

0.1 ± 0.7

0.07 ± 0.7

0.794

0.2 ± 0.7

−0.1 ± 0.5

0.206

0.1 ±0.7

0.006 ± 0.5

0.675

0.1 ± 0.7

−0.3 ± 0.5

0.223

  1. MRP Mean Resting Pressure, R asymmetry asymmetry of the resting sphincter, MSP Maximal Squeezing Pressure, S asymmetry asymmetry of the squeezing sphincter, HPZ High Pressure Zone, RAIR Recto-Anal Inhibitory Reflex, CIR Circumferential ratio.
  2. † For patients with tumor below 5 cm from the anal verge, the field of additional booster on peritumoral region included the anal canal. However, in tumor above 5 cm from the anal verge, the anal canal and perineum were excluded from the field of additional booster.
  3. * The negative value means that value of manometric data after nCRT was increased than that before nCRT.