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Table 2 Comparison of manometric data before nCRT according to each tumor characteristics

From: Short–term effects of neoadjuvant chemoradiation therapy on anorectal function in rectal cancer patients: a pilot study

 

Tumor location

Gross morphology

CIR

T stage

 

>5 cm (n = 18)

≤5 cm (n = 12)

P-value

UF (n = 22)

UI (n = 8)

P-value

R1 (n = 15)

R2 (n = 10)

R3 (n = 5)

P-value

T3 (n = 27)

T4 (n = 3)

P-value

MRP (mmHg)

89.4 ± 41.7

99.6 ± 50.1

0.550

97.8 ± 46.4

81.7 ± 39.9

0.393

79.6 ± 38.7

99.3 ± 38.4

123.5 ± 62.9

0.144

88.4 ± 43.6

138.8 ± 26.6

0.063

R asymmetry (%)

20.7 ± 5.8

24.6 ± 19.5

0.427

22.8 ± 14.5

20.8 ± 7.5

0.725

21.4 ± 6.8

17.6 ± 5.8

34.1 ± 27.3

0.059

23.1 ± 13.3

14.9 ± 3.9

0.310

MSP (mmHg)

313.7 ± 116.5

401.3 ± 238.2

0.189

345.9 ± 200.8

356.5 ± 94.4

0.888

319.7 ± 91.5

353.6 ± 121.6

425.9 ± 392.7

0.523

351.1 ± 183.7

328.5 ± 124.5

0.839

S asymmetry (%)

15.9 ± 4.1

19.2 ± 17.9

0.470

18.2 ± 13.3

14.7 ± 3.2

0.485

15.3 ± 4.2

13.9 ± 3.3

29.4 ± 25.6

0.029

17.8 ± 12.1

12.1 ± 2.2

0.424

HPZ length at rest (cm)

1.7 ± 0.6

1.9 ± 0.5

0.512

1.8 ± 0.6

1.6 ± 0.4

0.438

1.6 ± 0.5

1.7 ± 0.6

2.1 ± 0.7

0.416

1.7 ± 0.6

1.8 ± 0.7

0.829

HPZ length at squeezing (cm)

2.3 ± 0.5

2.1 ± 0.3

0.147

2.2 ± 0.5

2.1 ± 0.3

0.251

2.0 ± 0.3

2.3 ± 0.6

2.6 ± 0.4

0.059

2.1 ± 0.4

2.8 ± 0.7

0.017

RAIR (ml)

36.7 ± 14.1

38.3 ± 13.4

0.749

38.2 ± 8.5

35.0 ± 23.3

0.581

40.0 ± 13.1

36.0 ± 12.6

32 ± 17.8

0.504

37.1 ± 14.3

40.0 ± 0.1

0.728

Rectal sensory threshold (ml)

 

First

65.6 ± 37.9

59.2 ± 21.5

0.602

63.2 ± 35.1

62.5 ± 23.7

0.960

71.3 ± 41.5

59.0 ± 17.9

46.0 ± 0.5

0.258

62.9 ± 32.6

63.3 ± 32.1

0.985

Desire to defecate

116.1 ± 45.8

119.2 ± 49.4

0.863

116.8 ± 43.4

118.7 ± 57.4

0.922

204.0 ± 66.2

162.0 ± 57.3

179.3 ± 63.7

0.297

117.1 ± 45.1

120.0 ± 69.2

0.919

Maximal

174.4 ± 57.2

186.7 ± 74.5

0.615

167.2 ± 53.7

212.5 ± 80.3

0.086

204.0 ± 66.2

162.0 ± 57.3

140.0 ± 41.8

0.083

177.1 ± 65.4

200.0 ± 50.0

0.563

Rectal compliance (ml/mmHg)

1.4 ± 0.8

1.3 ± 0.7

0.852

1.2 ± 0.6

1.9 ± 1.1

0.035

1.8 ± 0.9

1.1 ± 0.5

0.8 ± 0.5

0.017

1.4 ± 0.8

1.0 ± 0.2

0.346

  1. MRP Mean Resting Pressure, R asymmetry asymmetry of the resting sphincter, MSP Maximal Squeezing Pressure, S asymmetry asymmetry of the squeezing sphincter, HPZ High Pressure Zone, RAIR Recto-Anal Inhibitory Reflex, UF Ulcerofungating type, UI Ulceroinfiltrative type, CIR Circumferential ratio, R1 1/4 < CIR ≤ 2/4, R2 2/4 < CIR ≤ 3/4, R3 CIR > 3/4.
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Radiation Oncology

ISSN: 1748-717X

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