Table 1 Baseline patient and tumor characteristics by HPV status
Variable | HPV-positive (97) | HPV-negative (24) | p-value |
|---|---|---|---|
Median age (range) | 56 (40-70) | 58 (45-73) | 0.23 |
Gender | 0.022 | ||
Male | 90 (93%) | 18 (75%) | |
Female | 7 (7%) | 6 (25%) | |
Race | 0.015 | ||
Caucasian | 93 (96%) | 19 (79%) | |
Other | 4 (4%) | 5 (21%) | |
KPS | < 0.001 | ||
≥90 | 89 (92%) | 14 (58%) | |
<90 | 8 (8%) | 10 (42%) | |
Tobacco use | 0.033 | ||
Current | 14 (14%) | 8 (33%) | |
Former | 50 (52%) | 13 (54%) | |
Never | 33 (34%) | 3 (13%) | |
Median pack years (range) | 10 (0-80) | 30 (0-100) | < 0.001 |
Moderate or greater alcohol use | 0.009 | ||
Ever | 10 (10%) | 8 (33%) | |
Never | 87 (90%) | 16 (67%) | |
Year of diagnosis (range) | 2009 (2006-2011) | 2009 (2007-2010) | 0.26 |
Primary site | 0.52 | ||
Base of tongue | 53 (55%) | 13 (54%) | |
Tonsil | 43 (44%) | 10 (42%) | |
Oropharyngeal wall | 1 (1%) | 1 (4%) | |
Median diameter, cm (range) | 2.8 (1.0-9.3) | 3.9 (1.5-7.0) | 0.002 |
Median follow-up, months (range) | 20.4 (5.8-63.0) | 24 (7.4-47.7) | 0.47 |