Table 6 Summary of differences between treatment plan and radiobiological parameters from the two algorithms for breast treatment

PTV

D_2%(Gy)

51.5

0.7

52.2

0.7

<0.001

D_95%(Gy)

47.1

0.8

48.7

0.6

<0.001

D_mean(Gy)

49.2

0.7

50.4

0.6

<0.001

II (%)

8.9

0.4

6.9

0.3

<0.001

TCP(%)

77.3

7.7

85.1

4.3

<0.001

Left Lung

D_2%(Gy)

44.1

1.3

48.0

1.6

<0.001

D_15%(Gy)

7.0

1.5

4.0

1.2

<0.001

D_mean(Gy)

5.9

1.2

4.1

1.2

<0.001

LKB model

NTCP (%)

Ref.

Emami et al. [39] / Burman et al. [23]

0.0

0.0

0.0

0.0

Kwa et al. [60]

0.2

0.1

0.1

0.0

<0.008

Seppenwoolde et al. [38]

0.7

0.1

0.6

0.1

<0.005

De Jeager et al. [24]^†

2.0

0.3

1.6

0.2

<0.001

De Jeager et al. [24]^††

2.1

0.3

1.8

0.2

<0.001

Seriality model

Emami et al. [39]/ Ågren-Cronqvist et al. [40]

0.0

0.0

0.0

0.0

Seppenwoolde et al. [38]

0.2

0.1

0.1

0.1

<0.001

Gagliardi et al. [61]

0.2

0.1

0.1

0.1

0.020

Heart

D_2%(Gy)

37.7

12.5

37.5

13.3

0.758

D_15%(Gy)

3.9

0.7

2.8

0.6

<0.001

LKB model

NTCP(%)

Ref.

Emami et al. [39] /Burman et al. [23]

0.0

0.0

0.0

0.0

Martel et al. [57]

0.0

0.0

0.0

0.0

Seriality model

Emami et al. [39]/Ågren-Cronqvist et al. [40]

0.0

0.0

0.0

0.0

Gagliardi et al. [58]

0.6

0.4

0.6

0.4

0.243

Eriksson et al. [59]

0.6

0.3

0.6

0.3

0.482

Eriksson et al. [59]

0.4

0.2

0.4

0.2

0.418