Capecitabine (n = 52), n | 5-FU (n = 46), n | ||||||||
---|---|---|---|---|---|---|---|---|---|
Type of toxic effect | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | p-value† |
Hematologic toxicity | |||||||||
Leukopenia | 22 | 8 | 0 | 0 | 6 | 9 | 1 | 1 | 0.007 |
Anemia | 36 | 1 | 0 | 0 | 23 | 7 | 2 | 0 | 0.022 |
Thrombocytopenia | 18 | 3 | 0 | 0 | 15 | 1 | 0 | 0 | 0.719 |
Nonhematologic toxicity | |||||||||
Hand-foot syndrome | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0.620 |
Anorexia | 19 | 0 | 0 | 0 | 18 | 2 | 1 | 0 | 0.283 |
Vomiting | 6 | 6 | 0 | 0 | 14 | 8 | 2 | 0 | 0.010 |
Diarrhea | 5 | 2 | 0 | 0 | 6 | 2 | 1 | 0 | 0.860 |
Constipation | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0.339 |
Abdominal pain | 14 | 1 | 0 | 0 | 12 | 1 | 0 | 0 | 1.000 |
Stomatitis | 21 | 0 | 0 | 0 | 30 | 0 | 0 | 0 | 0.016 |