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Table 2 Comparison of toxicities * between the capecitabine and 5-fluorouracil (5-FU) groups

From: Comparison of capecitabine and 5-fluorouracil in chemoradiotherapy for locally advanced pancreatic cancer

 

Capecitabine (n = 52), n

5-FU (n = 46), n

 

Type of toxic effect

Grade 1

Grade 2

Grade 3

Grade 4

Grade 1

Grade 2

Grade 3

Grade 4

p-value†

Hematologic toxicity

         

 Leukopenia

22

8

0

0

6

9

1

1

0.007

 Anemia

36

1

0

0

23

7

2

0

0.022

 Thrombocytopenia

18

3

0

0

15

1

0

0

0.719

Nonhematologic toxicity

         

 Hand-foot syndrome

3

0

0

0

1

0

0

0

0.620

 Anorexia

19

0

0

0

18

2

1

0

0.283

 Vomiting

6

6

0

0

14

8

2

0

0.010

 Diarrhea

5

2

0

0

6

2

1

0

0.860

 Constipation

1

0

0

0

3

0

0

0

0.339

 Abdominal pain

14

1

0

0

12

1

0

0

1.000

 Stomatitis

21

0

0

0

30

0

0

0

0.016

  1. Abbreviations: same as Table 1.
  2. Some patients experienced more than one toxicity.
  3. *National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0.
  4. Fisher’s exact test, two-tailed.